Abstract | OBJECTIVE: METHODS: After being established into chronic viral myocarditis model by 4 times repetitively infecting with gradient multiplicative CVB3m, 160 male mice were divided into the blank group, the model group, the TCM treated group and the Western medicine treated group. On the 10th, 30th and 60th day after the last time of infection, mice were killed to observe their pathological changes of myocardium with HE staining and to detect TGF-beta1 mRNA expression in myocardial tissue with semi-quantitative RT-PCR method. RESULTS: Pathological changes of myocardium alleviated, and TGF-beta1 mRNA expression distribution area reduced significantly in the two treated groups, as compared with those in the model group (all P < 0.05). CONCLUSION:
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Authors | Ying-wei Wang, Ling Guo, Qi-hong Li |
Journal | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
(Zhongguo Zhong Xi Yi Jie He Za Zhi)
Vol. 26
Issue 4
Pg. 341-3
(Apr 2006)
ISSN: 1003-5370 [Print] China |
PMID | 16689004
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drugs, Chinese Herbal
- RNA, Messenger
- Transforming Growth Factor beta1
- yiqi jiangzhuo
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Topics |
- Animals
- Coxsackievirus Infections
(drug therapy)
- Drugs, Chinese Herbal
(therapeutic use)
- Enterovirus B, Human
(drug effects)
- Gene Expression
(drug effects)
- Male
- Mice
- Myocarditis
(drug therapy, pathology, virology)
- Phytotherapy
- RNA, Messenger
(biosynthesis, genetics)
- Recurrence
- Reverse Transcriptase Polymerase Chain Reaction
- Transforming Growth Factor beta1
(genetics)
- Ventricular Remodeling
(drug effects, genetics, physiology)
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