3% Amuchina is as effective as the 50% concentration in the prevention of exit-site infection in children on chronic peritoneal dialysis.

Abstract

In a previous communication, we demonstrated that, in the prevention of exit-site infection (ESI) in children, the cleansing agent 50% Amuchina (electrolytic chloroxidizer. Amuchina SpA, Genoa, Italy) is more effective than 10% povidone iodine and as effective as 4% chlorhexidine, but with fewer adverse secondary effects. In the present study, we assessed, in an Argentine pediatric population, whether Amuchina 3% is as effective as Amuchina 50% in preventing ESI in children on chronic peritoneal dialysis. In an open-label, single-center prospective study, 27 children (mean age: 7.2 years; range: 1.7-17 years) used 3% Amuchina as a cleansing agent for the daily care of a healthy exit site. Of the 27 children, 14 were switched from 50% Amuchina to 3% Amuchina, and 13 were using the 3% Amuchina for the first time. The control group consisted of 18 patients who had previously used 50% Amuchina as a cleansing agent. We followed the recommendations of the International Society for Peritoneal Dialysis with regard to exit-site care, which include keeping the cleansing agent out of the sinus and rinsing the exit site with sterile water. Amuchina was used from the first post-implantation care of the exit site. No adverse secondary effects were seen with the use of Amuchina at either concentration. Patients using 3% Amuchina presented an ESI rate similar to that of patients using Amuchina 50%. The cost of 3% Amuchina was significantly lower than that of the 50% concentration, and it was even lower than the cost for 10% povidone iodine or 4% chlorhexidine. Although more research trials are needed to assess the efficacy of 3% Amuchina, we conclude that 3% Amuchina is the best and most cost-effective cleansing agent for the daily care of a healthy exit site in children on chronic peritoneal dialysis.

• Authors: Mònica D Grosman, Vanesa M Mosquera, Maria G Hernandez, Silvana Agostini, Marta Adragna, Ernesto T Sojo
• Journal: Advances in peritoneal dialysis. Conference on Peritoneal Dialysis (Adv Perit Dial) Vol. 21 Pg. 148-50 ( 2005) ISSN: 1197-8554 [Print] Canada
• PMID: 16686307 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Amuchina
• Anti-Infective Agents, Local
• Sodium Chloride
• Hypochlorous Acid

Topics

• Adolescent
• Anti-Infective Agents, Local (administration & dosage)
• Bacterial Infections (prevention & control)
• Catheters, Indwelling (adverse effects)
• Child
• Child, Preschool
• Humans
• Hypochlorous Acid (administration & dosage)
• Infant
• Peritoneal Dialysis
• Peritoneal Dialysis, Continuous Ambulatory
• Sodium Chloride (administration & dosage)