Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: No association was found in four polymorphisms in angiotensinogen and angiotensin-converting enzyme. Prolylcarboxypeptidase E112D (rs2298668) D allele along and jointly with chronic hypertension were associated with a significantly increased risk of preeclampsia. Compared to women with homozygous EE genotype and without chronic hypertension, higher risks of preeclampsia were observed in DD women without chronic hypertension (OR = 3.7, 95% CI, 1.2 - 12.4) and EE women with chronic hypertension (OR = 9.1, 95% CI: 4.7 - 17.6). Women with both D allele and chronic hypertension had the highest risk (OR = 158, 95% CI, 25-infinite). This finding was validated in an independent sample of 1,015 non-black women. We further compared the prolylcarboxypeptidase transcript levels in peripheral blood cells of 23 preeclamptic (30% with chronic hypertension) and 51 non-preeclamptic (6% with chronic hypertension) women 2 - 3 days after delivery. The PRCP transcript levels were lower in ED/DD women than in EE woman (P = .03) and lower in preeclamptic women than in non-preeclamptic women (P = .007). CONCLUSION:
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Authors | Lin Wang, Yan Feng, Yan Zhang, Huanyu Zhou, Shanqun Jiang, Tianhua Niu, Lee-Jen Wei, Xin Xu, Xiping Xu, Xiaobin Wang |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 195
Issue 1
Pg. 162-71
(Jul 2006)
ISSN: 1097-6868 [Electronic] United States |
PMID | 16681991
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensinogen
- Carboxypeptidases
- Peptidyl-Dipeptidase A
- lysosomal Pro-X carboxypeptidase
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Topics |
- Adult
- Black or African American
(genetics)
- Angiotensinogen
(genetics)
- Boston
(epidemiology)
- Carboxypeptidases
(genetics)
- Case-Control Studies
- Chronic Disease
- Female
- Gene Expression
- Genotype
- Humans
- Hypertension
(genetics)
- Odds Ratio
- Peptidyl-Dipeptidase A
(genetics)
- Phenotype
- Polymorphism, Single Nucleotide
- Pre-Eclampsia
(epidemiology, genetics)
- Pregnancy
- Renin-Angiotensin System
(genetics)
- White People
(genetics)
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