Abstract | BACKGROUND: AIM: To verify whether chronic tadalafil (CT) preserves bilateral cavernous neurotomy (BCN)-induced penile damage and hypo-oxygenation. METHODS: In a rat model of BCN we evaluated in vitro and ex vivo effect of CT treatment (2 mg/kg, daily for 3 months). RESULTS: CONCLUSION: Chronic tadalafil restores some of the investigated BCN-induced alterations, including PDE5 and tadalafil efficacy.
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Authors | Linda Vignozzi, Sandra Filippi, Annamaria Morelli, Stefano Ambrosini, Michaela Luconi, Gabriella Barbara Vannelli, Silvia Donati, Clara Crescioli, Xin-Hua Zhang, Vincenzo Mirone, Gianni Forti, Mario Maggi |
Journal | The journal of sexual medicine
(J Sex Med)
Vol. 3
Issue 3
Pg. 419-31
(May 2006)
ISSN: 1743-6095 [Print] Netherlands |
PMID | 16681467
(Publication Type: Journal Article)
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Chemical References |
- Carbolines
- Endothelins
- Nitric Oxide Donors
- Peptide Fragments
- Phosphodiesterase Inhibitors
- Vasodilator Agents
- sovateltide
- Nitroprusside
- Tadalafil
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Topics |
- Animals
- Carbolines
(administration & dosage)
- Cell Hypoxia
(drug effects)
- Disease Models, Animal
- Endothelins
(pharmacology)
- Erectile Dysfunction
(drug therapy, etiology)
- Male
- Nitric Oxide Donors
(pharmacology)
- Nitroprusside
(pharmacology)
- Penile Erection
- Penis
(blood supply, innervation)
- Peptide Fragments
(pharmacology)
- Phosphodiesterase Inhibitors
(administration & dosage)
- Prostatectomy
(adverse effects)
- Rats
- Rats, Sprague-Dawley
- Tadalafil
- Vasodilator Agents
(administration & dosage)
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