Abstract | OBJECTIVES: STUDY DESIGN: This was a prospective, open-label clinical study. MATERIAL AND METHOD: A total of 44 eyes of 22 eligible patients whose intraocular pressure (IOP) was inadequately controlled by topical beta-blocker were enrolled. Inclusion criteria consisted of patients with primary open angle glaucoma who either had IOP measurements > or = 22 mmHg while on topical beta-blocker monotherapy or had IOP measurements > or = 18 mmHg while on dual therapy (topical beta-blocker and a second drug of a different class which was to be discontinued prior to the study to allow washing out of its effects). INTERVENTION: Baseline IOP, pupil size, blood pressure and pulse rate were initially measured; the patients were then examined at 2nd, 4th, 8th, 12th, 18th and 24th weeks of following commencement of topical unoprostone isopropyl therapy (given twice daily). MAIN OUTCOME MEASURES: IOP pupil size, blood pressure and pulse rate were measured and were compared to baseline values. RESULTS: In 44 eyes of 22 eligible patients, unoprostone isopropyl resulted in a statistically significant IOP reduction of 24.6% (p < 0.02). The mean systolic blood pressure decreased from 132.79 +/- 22.11 mmHg (range 100-180 mmHg) at baseline to 125.77 +/- 18.40 mmHg (range 80-160 mmHg) at 24th week after unoprostone isopropyl administration. This reduction was statistically significant (p = 0.002) but was unlikely to have clinical importance. Both mean diastolic blood pressure (p = 0.344), pulse rate (p = 0.306), and pupil diameter (p = 0.107) were not significantly affected. CONCLUSION:
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Authors | Yupin Leelachaikul, Ataya Euswas |
Journal | Journal of the Medical Association of Thailand = Chotmaihet thangphaet
(J Med Assoc Thai)
Vol. 88 Suppl 9
Pg. S100-4
(Nov 2005)
ISSN: 0125-2208 [Print] Thailand |
PMID | 16681060
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Adrenergic beta-Antagonists
- Ophthalmic Solutions
- isopropyl unoprostone
- Dinoprost
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Topics |
- Administration, Topical
- Adrenergic beta-Antagonists
(administration & dosage)
- Adult
- Aged
- Aged, 80 and over
- Dinoprost
(administration & dosage, analogs & derivatives)
- Dose-Response Relationship, Drug
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Glaucoma, Open-Angle
(diagnosis, drug therapy)
- Humans
- Intraocular Pressure
- Male
- Middle Aged
- Ophthalmic Solutions
- Prospective Studies
- Risk Assessment
- Severity of Illness Index
- Single-Blind Method
- Tonometry, Ocular
- Treatment Outcome
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