Video capsule endoscopy in peutz-jeghers syndrome: a blinded comparison with barium follow-through for detection of small-bowel polyps.

Abstract

BACKGROUND AND STUDY AIMS:

Video capsule endoscopy has shown promise for the surveillance of significant small-bowel polyps in patients with Peutz-Jeghers syndrome. In this study the yield of significant small-bowel polyps by capsule endoscopy was compared to the yield of these polyps by barium follow-through in adults with Peutz-Jeghers syndrome.

PATIENTS AND METHODS:

A total of 19 adults with Peutz-Jeghers syndrome who were undergoing surveillance underwent both capsule endoscopy and barium follow-through examinations, and the number of small-bowel polyps of at least 1 cm in diameter that were detected was recorded for each method. The two methods were assessed in terms of comfort and convenience for the patients and their preferred future surveillance method, using a questionnaire.

RESULTS:

Capsule endoscopy detected a median of four significant small-bowel polyps while barium follow-through detected a median of one (P = 0.008). There was a trend towards more participants having at least one significant small-bowel polyp detected by capsule endoscopy than was the case with barium follow-through, though capsule endoscopy seemed to be less reliable for accurate sizing of polyps that were at the limit of clinical significance. Most participants expressed a preference for capsule endoscopy for future surveillance.

CONCLUSIONS:

Capsule endoscopy should replace barium follow-through for the surveillance of small-bowel polyps in adults with Peutz-Jeghers syndrome, but the findings of this study should be interpreted with caution until a more reliable means of sizing polyps by capsule endoscopy is available.

• Authors: G Brown, C Fraser, G Schofield, S Taylor, C Bartram, R Phillips, B Saunders
• Journal: Endoscopy (Endoscopy) Vol. 38 Issue 4 Pg. 385-90 (Apr 2006) ISSN: 0013-726X [Print] Germany
• PMID: 16680639 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Contrast Media
• Barium Sulfate

Topics

• Administration, Oral
• Adult
• Barium Sulfate (administration & dosage)
• Contrast Media (administration & dosage)
• Endoscopes, Gastrointestinal
• Endoscopy, Gastrointestinal (methods)
• Female
• Humans
• Intestine, Small (diagnostic imaging, pathology)
• Male
• Middle Aged
• Miniaturization (instrumentation)
• Peutz-Jeghers Syndrome (diagnosis)
• Radiography
• Reproducibility of Results
• Surveys and Questionnaires