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[Inhibitors for protein tyrosine kinases, erbstatin, genistein and herbimycin A, induce differentiation of human neural tumor cell lines].

Abstract
Recent reports suggest that protein phosphorylation is involved in neural differentiation. We have found that specific inhibitors of protein phosphorylation at tyrosine residues, Erbstatin, Genistein, Herbimycin A, effectively induce neural differentiation in a human neuroblastoma cell line SK-N-DZ and a human medulloblastoma cell line Med-3, as indicated by the marked increase in the number of neurites/cell and in the expression of neurofilaments (160 k) detected by immunohistochemical studies. Possible involvement of protein phosphorylation at tyrosine residues in the differentiation of neural tumor cells was stressed.
AuthorsM Matsumoto
JournalNihon geka hokan. Archiv fur japanische Chirurgie (Nihon Geka Hokan) Vol. 60 Issue 2 Pg. 113-21 (Mar 01 1991) ISSN: 0003-9152 [Print] Japan
PMID1668058 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antibiotics, Antineoplastic
  • Benzoquinones
  • Hydroquinones
  • Isoflavones
  • Lactams, Macrocyclic
  • Neurofilament Proteins
  • Quinones
  • Rifabutin
  • herbimycin
  • Genistein
  • Protein-Tyrosine Kinases
  • erbstatin
Topics
  • Antibiotics, Antineoplastic (pharmacology)
  • Benzoquinones
  • Cell Differentiation (drug effects)
  • Genistein
  • Humans
  • Hydroquinones (pharmacology)
  • Immunohistochemistry
  • Isoflavones (pharmacology)
  • Lactams, Macrocyclic
  • Neoplasms, Nerve Tissue (metabolism, pathology)
  • Neurofilament Proteins (metabolism)
  • Protein-Tyrosine Kinases (antagonists & inhibitors)
  • Quinones (pharmacology)
  • Rifabutin (analogs & derivatives)
  • Tumor Cells, Cultured (drug effects, pathology)

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