Therapeutic effects of beta-thujaplicin eardrops on canine Malassezia-related otitis externa.

Abstract

An eardrop solution of beta-thujaplicin was examined for therapeutic effects on canine Malassezia-related otitis externa. Half to one ml of beta-thujaplicin solution of 100 microg/ml including DMSO 2% was injected everyday into both external ear canals of 31 cases for test-of-cure agreement. Fifteen score phases were established from the symptoms and cerumen smear biopsy findings, and score changes were recorded at least once a week. The means of the second and the third inspection day scores decreased significantly more than the previous value of each. In addition, the numbers of yeast-like organisms clearly decreased. These results suggest that beta-thujaplicin eardrops are effective for Malassezia-related otitis externa in dogs.

• Authors: Yasuyuki Nakano, Saburo Matsuo, Hiroyuki Tani, Kazumi Sasai, Eiichiroh Baba
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 68 Issue 4 Pg. 373-4 (Apr 2006) ISSN: 0916-7250 [Print] Japan
• PMID: 16679729 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Anti-Infective Agents
• Monoterpenes
• Tropolone
• beta-thujaplicin

Topics

• Animals
• Anti-Infective Agents (administration & dosage, therapeutic use)
• Dermatomycoses (drug therapy, microbiology, veterinary)
• Dog Diseases (drug therapy, microbiology)
• Dogs
• Malassezia (drug effects, physiology)
• Monoterpenes (administration & dosage, therapeutic use)
• Otitis Externa (drug therapy, microbiology, veterinary)
• Time Factors
• Tropolone (administration & dosage, analogs & derivatives, therapeutic use)