HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A comparison of biodistribution between 111In-DTPA octreotide and 111In-DOTATOC in rats bearing pancreatic tumors.

Abstract
111In-DTPA octreotide (DTPAOC) has been used for detecting somatostatin receptor positive tumor for years. In-111 DOTA-Tyr3-octreotide (DOTATOC) is newly developed for diagnostic and therapeutic purposes. In this study, we compared the biodistribution and tumor uptake ratio after injection of In-111 DTPAOC and In-111 DOTATOC in rats. Twelve rats bearing pancreatic tumors were divided into two groups: six rats were sacrificed at 4 hr after injection of 3.7 MBq of In-111 DTPAOC and another 6 rats were sacrificed at the same time after injection of 3.7 MBq of In-111 DOTATOC. Samples of various organs were obtained and counted to calculate the tissue concentration. In addition, 12 rats bearing pancreatic tumors were scanned at 4, 24, and 48 hr after injection of 37 MBq of In-111 DTPAOC or In-111 DOTATOC. The tumor uptake ratios (T/N ratio) were calculated. The biodistribution data showed that the activity in the tumor as well as in the kidney was significantly higher in the In-111 DOTATOC group than in the In-111 DTPAOC group, although both radiopharmaceuticals had the expected high affinity to the tumor. The T/N ratios in the In-111 DOTATOC group were also significantly higher than those in the In-111 DTPAOC group at 24 hr after injection. We conclude that In-111 DOTATOC showed lower clearance than In-111 DTPAOC in the rats bearing pancreatic tumors, although both of these radiopharmaceuticals showed expected high tumor uptake.
AuthorsYung-Chang Lin, Guang-Uei Hung, Tsai-Yueh Luo, Chun-Hsiung Chen, Chien-Chung Hsia, Shu-Ling Hen, Yung-Jen Ho, Wan-Yu Lin
JournalThe Journal of veterinary medical science (J Vet Med Sci) Vol. 68 Issue 4 Pg. 367-71 (Apr 2006) ISSN: 0916-7250 [Print] Japan
PMID16679728 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Indium Radioisotopes
  • Radiopharmaceuticals
  • SDZ 215-811
  • Pentetic Acid
  • Octreotide
  • Edotreotide
Topics
  • Animals
  • Indium Radioisotopes (blood, metabolism, pharmacokinetics)
  • Male
  • Neuroendocrine Tumors (metabolism)
  • Octreotide (analogs & derivatives, blood, metabolism, pharmacokinetics)
  • Pancreatic Neoplasms (metabolism)
  • Pentetic Acid (analogs & derivatives, blood, metabolism, pharmacokinetics)
  • Radiopharmaceuticals (blood, metabolism, pharmacokinetics)
  • Rats
  • Rats, Inbred Lew
  • Tissue Distribution

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: