Effect of olean-9(11), 12-diene-3 beta, 30-diol 3 beta, o-hemisuccinate Na salt, a glycyrrhetinic acid derivative, on peroxidation in CCl4 induced mouse acute hepatitis.

Abstract

Anti-hepatitis effect of the olean-9(11),12-diene-3 b, 30-diol 3 b, o-hemisuccinate Na Salt (III b), a glycyrrhetinic acid derivative, was studied in CCl4 induced mouse. The mouse was administered i.p. with 0.1 mole/kg or 0.2 mole/kg of III b, then followed by 31.4 microliters/kg of CCl4. III b was shown to promote the activity of the glucose-6-phosphatase, lower the content of malondialdehyde, and prevent the activity from the soluble enzyme(i.e. GPT, GOT, LDH) from flowing out in the serum enzyme and liver homogenate. III b had the similar anti-peroxidation effect as vitamin E and can maintain the liver function.

• Authors: W T Huang
• Journal: The American journal of Chinese medicine (Am J Chin Med) Vol. 19 Issue 2 Pg. 115-20 ( 1991) ISSN: 0192-415X [Print] Singapore
• PMID: 1667846 (Publication Type: Journal Article)

Chemical References

• olean-9(11),12-diene-3,30-diol 3-O-hemisuccinate
• Malondialdehyde
• Carbon Tetrachloride
• L-Lactate Dehydrogenase
• Aspartate Aminotransferases
• Alanine Transaminase
• Alkaline Phosphatase
• Glucose-6-Phosphatase
• Glycyrrhetinic Acid

Topics

• Alanine Transaminase (blood, metabolism)
• Alkaline Phosphatase (blood, metabolism)
• Animals
• Aspartate Aminotransferases (blood, metabolism)
• Carbon Tetrachloride
• Chemical and Drug Induced Liver Injury (blood, drug therapy, metabolism)
• Drug Evaluation, Preclinical
• Glucose-6-Phosphatase (blood, metabolism)
• Glycyrrhetinic Acid (administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
• L-Lactate Dehydrogenase (blood, metabolism)
• Lipid Peroxidation (drug effects)
• Male
• Malondialdehyde (blood, metabolism)
• Mice