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Vaccine potential of influenza vectors expressing Mycobacterium tuberculosis ESAT-6 protein.

Abstract
We generated several attenuated recombinant influenza A vectors expressing the Mycobacterium tuberculosis early secretory antigenic target (ESAT-6) protein. The ESAT-6 protein was recently identified as one of the most promising protective antigens for cell-mediated immunity. The obtained vectors appeared to be capable of inducing ESAT-6 specific Th1 immune response in mice after intranasal immunization. We found that double immunization with two influenza vectors of different subtypes provided a significant level of protection in mice, when applied as prophylactic vaccine, as well as substantial therapeutic effect in mice with pre-established tuberculosis infection. Moreover, we found a strong synergistic effect when vaccination with Flu/ESAT-6 vectors was combined with isoniazid treatment, resulting in a dramatic reduction of bacterial load in the lungs of infected mice.
AuthorsM A Stukova, S Sereinig, N V Zabolotnyh, B Ferko, C Kittel, J Romanova, T I Vinogradova, H Katinger, O I Kiselev, A Egorov
JournalTuberculosis (Edinburgh, Scotland) (Tuberculosis (Edinb)) 2006 May-Jul Vol. 86 Issue 3-4 Pg. 236-46 ISSN: 1472-9792 [Print] Scotland
PMID16677861 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, Bacterial
  • Antitubercular Agents
  • Bacterial Proteins
  • ESAT-6 protein, Mycobacterium tuberculosis
  • Tuberculosis Vaccines
  • Isoniazid
Topics
  • Administration, Intranasal
  • Animals
  • Antigens, Bacterial (genetics, immunology, therapeutic use)
  • Antitubercular Agents (therapeutic use)
  • Bacterial Proteins (genetics, immunology, therapeutic use)
  • Combined Modality Therapy
  • Genetic Vectors (administration & dosage)
  • Immunity, Cellular
  • Immunization (methods)
  • Influenza A virus (genetics)
  • Isoniazid (therapeutic use)
  • Mice
  • Mice, Inbred C57BL
  • Mycobacterium tuberculosis (immunology)
  • Th1 Cells (immunology)
  • Tuberculosis (immunology, prevention & control, therapy)
  • Tuberculosis Vaccines (immunology, therapeutic use)

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