Abstract | BACKGROUND: METHODS: Dyspeptic patients who exhibited no abnormalities on laboratory blood and urine testing, abdominal ultrasonography and upper gastrointestinal endoscopy were randomized to receive camostat mesilate 200 mg three times daily or famotidine 20 mg twice daily for 4 weeks. Symptoms severity was recorded before and at 2 and 4 weeks after starting treatment using a visual analog scale. RESULTS: Epigastralgia was significantly improved after 2 and 4 weeks of treatment in both groups (P < 0.01); this improvement tended to be more marked in the camostat mesilate group (P < 0.05 at 2 weeks). The beneficial effect of camostat mesilate on epigastralgia was more prominent in chronic alcohol drinkers at 2 weeks (P < 0.05) and 4 weeks (P < 0.01). CONCLUSIONS:
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Authors | Nobuo Ashizawa, Tomoyuki Hashimoto, Tatsuya Miyake, Toshihiro Shizuku, Tomonori Imaoka, Yoshikazu Kinoshita |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 21
Issue 4
Pg. 767-71
(Apr 2006)
ISSN: 0815-9319 [Print] Australia |
PMID | 16677167
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Anti-Ulcer Agents
- Esters
- Guanidines
- Trypsin Inhibitors
- camostat
- Gabexate
- Famotidine
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Topics |
- Anti-Ulcer Agents
(therapeutic use)
- Dyspepsia
(diagnosis, drug therapy)
- Esters
- Famotidine
(therapeutic use)
- Female
- Gabexate
(analogs & derivatives, therapeutic use)
- Guanidines
- Humans
- Japan
- Male
- Middle Aged
- Treatment Outcome
- Trypsin Inhibitors
(therapeutic use)
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