Sixteen strains of Clostridium difficile (C.d) were isolated from 29 patients with
antibiotic-associated diarrhoea (AAD). 9 of 14 C.d positive and 1 of 6 C.d negative fecal specimens were detected as
cytotoxin positive. 10 AAC patients received colonoscopy and 6 had congestion,
edema and erosion of mucosa. Three had yellow-white pseudomembrane on the surface of colon. In 17 Clostridium difficile
enterocolitis (
CDEC) was diagnosed by C.d isolation,
cytotoxin detection and (or) colonoscopic finding. All the 17 patients received
antibiotics before diarrhoea. The risk
antibiotics were
gentamycin,
ampicillin and
cephalosporin. Of 17
CDEC, 4 were cured when the complicated
antibiotics were discontinued. 7 received
vancomycin therapy. 6 cured but 1 had once symptomatic recurrence and C.d re-appearance. 4 were cured by
metronidazole. 2 patients died of
CDEC and
respiratory failure prospectively before diagnosis. Eleven fecal specimens of
CDEC were analysed for intestinal microflora. The results showed that E. coli and Bifidobacteria in
CDEC patients were significantly lower.