Antiviral activity of constituents of Tamus communis.

Abstract

The antiviral activity of the phenanthrene derivatives 1-6, of the spyrostane triglycosides dioscin (7) and gracillin (8), of the furostanol tetraglycosides methylprotodioscin (9), its (25S) epimer methylprotoneodioscin (10), and methylprotogracillin 11, have been tested towards two RNA viruses: vesicular stomatitis virus and human rhinovirus type 1B. All these products were extracted from the rizomes of Tamus communis L; compound 11 was isolated also from Asparagus cochinchinesis, together with pseudoprotodioscin (12), a 20 (22)-unsaturated furostanoside, which was also investigated for antiviral activity. The results were of some interest mainly for the phenanthrene derivatives.

• Authors: R Aquino, C Conti, F De Simone, N Orsi, C Pizza, M L Stein
• Journal: Journal of chemotherapy (Florence, Italy) (J Chemother) Vol. 3 Issue 5 Pg. 305-9 (Oct 1991) ISSN: 1120-009X [Print] England
• PMID: 1667189 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• RNA, Viral
• Spirostans
• gracillin
• dioscin
• Diosgenin

Topics

• Animals
• Antiviral Agents (pharmacology)
• Cell Division (drug effects)
• Cells, Cultured
• Diosgenin (analogs & derivatives, pharmacology)
• HeLa Cells
• Humans
• Plants, Medicinal
• RNA, Viral
• Rhinovirus (drug effects, physiology)
• Spirostans (pharmacology)
• Vesicular stomatitis Indiana virus (drug effects, physiology)
• Virus Replication (drug effects)