Sleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia.

To evaluate the efficacy of sleep hygiene and melatonin treatment for initial insomnia in children with attention-deficit/hyperactivity disorder (ADHD).
Twenty-seven stimulant-treated children (6-14 years of age) with ADHD and initial insomnia (>60 minutes) received sleep hygiene intervention. Nonresponders were randomized to a 30-day double-blind, placebo-controlled, crossover trial of 5-mg pharmaceutical-grade melatonin provided by the study's sponsor.
Sleep hygiene reduced initial insomnia to <60 minutes in 5 cases, with an overall effect size in the group as a whole of 0.67. Analysis of the trial data able to be evaluated showed a significant reduction in initial insomnia of 16 minutes with melatonin relative to placebo, with an effect size of 0.6. Adverse events were generally mild and not different from those recorded with placebo treatment. The effect size of the combined sleep hygiene and melatonin intervention from baseline to 90 days' posttrial was 1.7, with a mean decrease in initial insomnia of 60 minutes. Improved sleep had no demonstrable effect on ADHD symptoms.
Combined sleep hygiene and melatonin was a safe and effective treatment for initial insomnia in children with ADHD taking stimulant medication.
AuthorsMargaret D Weiss, Michael B Wasdell, Melissa M Bomben, Kathleen J Rea, Roger D Freeman
JournalJournal of the American Academy of Child and Adolescent Psychiatry (J Am Acad Child Adolesc Psychiatry) Vol. 45 Issue 5 Pg. 512-9 (May 2006) ISSN: 0890-8567 [Print] United States
PMID16670647 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Melatonin
  • Adolescent
  • Arousal (drug effects)
  • Attention Deficit Disorder with Hyperactivity (diagnosis, drug therapy)
  • Child
  • Circadian Rhythm (drug effects)
  • Cross-Over Studies
  • Double-Blind Method
  • Education
  • Female
  • Health Education
  • Humans
  • Male
  • Melatonin (adverse effects, therapeutic use)
  • Sleep Initiation and Maintenance Disorders (diagnosis, drug therapy)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: