Efficacy of contact lens storage solutions against different acanthamoeba strains.

Abstract

PURPOSE:

This study was undertaken in order to determine the susceptibility of acanthamoebae to various contact lens disinfecting systems, with respect to type of disinfectant and exposure time.

METHODS:

Ten contact lens solutions, including one new system, were tested for their effectivities against cysts of three Acanthamoeba strains. Of main interest was an incubation time of 8 hours (overnight disinfection) and cyst quantities of 10 and 10, respectively.

RESULTS:

Boston Advance (polyaminopropyl biguanide 0.0005%, chlorhexidine 0.003%) for the storage of rigid gas permeable contact lenses destroyed the cysts of all strains at either concentration within one hour of exposure. Meni Care Plus (polyhexamethylene biguanide 0.0005%) also destroyed 10 cysts of all strains, however, 10 cysts only of two strains within one hour; after an exposure time of 8 hours all cysts were killed. The disinfecting solutions for soft contact lenses did not kill 10 cysts of either strain after 8 hours of incubation time.

CONCLUSION:

Two of the tested contact lens solutions (the ones for rigid gas permeable lenses) destroyed the cysts of all strains. One of these, containing a combination of two amoebicidal ingredients even after only one hour of exposure time.

• Authors: Klaus Hiti, Julia Walochnik, Eva Maria Haller-Schober, Christoph Faschinger, Horst Aspöck
• Journal: Cornea (Cornea) Vol. 25 Issue 4 Pg. 423-7 (May 2006) ISSN: 0277-3740 [Print] United States
• PMID: 16670479 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Biguanides
• Contact Lens Solutions
• Disinfectants
• polyaminopropylbiguanide
• polihexanide
• chlorhexidine gluconate
• Chlorhexidine

Topics

• Acanthamoeba (classification, drug effects, growth & development)
• Animals
• Biguanides (pharmacology)
• Chlorhexidine (analogs & derivatives, pharmacology)
• Contact Lens Solutions (pharmacology)
• Contact Lenses, Hydrophilic
• Disinfectants (pharmacology)
• Disinfection (methods)
• Drug Therapy, Combination
• Equipment Contamination
• Time Factors