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Evaluation of a diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b vaccine given concurrently with meningococcal group C conjugate vaccine at 2, 3 and 4 months of age.

AbstractBACKGROUND AND OBJECTIVE:
In view of the possible introduction of diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (DTaP-IPV-Hib, eg Pediacel) vaccine in the UK, a study of the immunogenicity of Pediacel when given with one of two different meningococcal group C conjugate (MCC) vaccines at 2, 3 and 4 months of age was conducted.
METHODS:
Randomised controlled study in 241 infants.
RESULTS:
Post vaccination, the proportion of infants with anti-polyribosylribitol phosphate (PRP) levels > or =0.15 microg/ml was 93.2% (95% confidence interval (CI) 86.6 to 96.7) in the Pediacel group compared with 100% (95% CI 96.4 to 100) in the diphtheria-tetanus-whole-cell pertussis-Haemophilus influenzae type b (DTwP-Hib) group. The anti-PRP response was lower in infants receiving either Pediacel or DTwP-Hib when these vaccines were given concomitantly with meningococcal group C conjugate with diphtheria-derived protein CRM(197) as conjugate protein (MCC-CRM) compared with meningococcal group C conjugate with tetanus toxoid as conjugate protein (MCC-TT). For group C meningococcus, the proportion of infants with serum bactericidal antibody (SBA) titre > or =1:8 in the Pediacel group was 99.0% compared with 100% in the DTwP-Hib group. The MCC SBA geometric mean titre (GMT) was lower in those receiving Pediacel with MCC-TT than in those receiving DTwP-Hib with MCC-TT, although all titres were well above the protective threshold. The MCC SBA GMT was similar in those receiving Pediacel and DTwP-Hib and MCC-CRM. Responses to all other vaccine components were equivalent in the two groups.
CONCLUSIONS:
Pediacel is immunogenic when given at 2, 3 and 4 months of age. Coadministration of MCC vaccine can influence the Hib response, and the MCC response to a tetanus conjugate can be influenced by the nature of the coadministered DTP-Hib vaccine.
AuthorsN R E Kitchin, J Southern, R Morris, F Hemme, S Thomas, M W Watson, K Cartwright, E Miller
JournalArchives of disease in childhood (Arch Dis Child) Vol. 92 Issue 1 Pg. 11-6 (Jan 2007) ISSN: 1468-2044 [Electronic] England
PMID16670121 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Diphtheria-Tetanus-acellular Pertussis Vaccines
  • Haemophilus Vaccines
  • Influenza Vaccines
  • Meningococcal Vaccines
  • Poliovirus Vaccine, Inactivated
  • Vaccines, Conjugate
  • diphtheria-tetanus-pertussis-haemophilus b conjugate vaccine
Topics
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Diphtheria-Tetanus-acellular Pertussis Vaccines (administration & dosage, immunology)
  • Dose-Response Relationship, Immunologic
  • Haemophilus Vaccines (administration & dosage, immunology)
  • Humans
  • Infant
  • Influenza Vaccines (administration & dosage, immunology)
  • Meningococcal Vaccines (administration & dosage, immunology)
  • Poliovirus Vaccine, Inactivated (administration & dosage, immunology)
  • Vaccines, Conjugate (administration & dosage, immunology)

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