Recent clinical experience with dronabinol.

Abstract

Dronabinol, delta-9-tetrahydrocannabinol in sesame oil, has been used for several years as an antiemetic for patients receiving cancer chemotherapy. In combination studies with prochlorperazine, enhancement of efficacy, as measured by duration of episodes of nausea and vomiting and by severity of nausea, has been found. The incidence of psychotropic effects from dronabinol appears to be decreased by concomitant administration of prochlorperazine. In open pilot studies, dronabinol caused weight gain in seven of ten patients with symptomatic HIV infection. In both HIV and cancer patients, dronabinol improved appetite at a dose which was well tolerated for chronic administration.

• Authors: T F Plasse, R W Gorter, S H Krasnow, M Lane, K V Shepard, R G Wadleigh
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 40 Issue 3 Pg. 695-700 (Nov 1991) ISSN: 0091-3057 [Print] United States
• PMID: 1666930 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Dronabinol

Topics

• Antineoplastic Agents (adverse effects)
• Appetite (drug effects)
• Dronabinol (therapeutic use)
• HIV Infections (complications, psychology)
• Humans
• Vomiting (chemically induced, drug therapy)