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Tumor necrosis factor-alpha inhibition and VATER association: a causal relationship.

Abstract
Inflammatory conditions that may require the use of a tumor necrosis factor-a (TNF-a) antagonist often involve women of child-bearing age. TNF-a antagonists are presumed to be safe in pregnancy based on animal data. However, this has never been formally studied in prospective trials involving humans. We describe a patient with psoriasis and psoriatic arthritis who took etanercept 50 mg subcutaneously (SQ) twice weekly throughout her pregnancy. She gave birth to a child with VATER association. Animal and human data exist to suggest a possible causal relationship between the mother's use of etanercept and the child's development of VATER association. We propose that the TNF antagonists, specifically etanercept, be used with caution in pregnant women. Patient registries of women who take TNF-a antagonists during pregnancy also need to be followed to see if there is an increase in the birth defects that are part of VATER association.
AuthorsJohn D Carter, Joanne Valeriano, Frank B Vasey
JournalThe Journal of rheumatology (J Rheumatol) Vol. 33 Issue 5 Pg. 1014-7 (May 2006) ISSN: 0315-162X [Print] Canada
PMID16652431 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antirheumatic Agents
  • Immunoglobulin G
  • Receptors, Tumor Necrosis Factor
  • Tumor Necrosis Factor-alpha
  • Etanercept
Topics
  • Abnormalities, Multiple (etiology)
  • Adult
  • Antirheumatic Agents (adverse effects, therapeutic use)
  • Arthritis, Psoriatic (drug therapy)
  • Etanercept
  • Female
  • Humans
  • Immunoglobulin G (adverse effects, therapeutic use)
  • Pregnancy
  • Pregnancy Complications (drug therapy)
  • Receptors, Tumor Necrosis Factor (therapeutic use)
  • Tumor Necrosis Factor-alpha (antagonists & inhibitors, physiology)

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