The anti-gastropathic and anti-rheumatic effect of niga-ichigoside F1 and 23-hydroxytormentic acid isolated from the unripe fruits of Rubus coreanus in a rat model.

Abstract

This study was undertaken to produce the clinical merits of two natural antinociceptive anti-inflammatory triterpenoids which synthetic anti-inflammatory drugs do not have. The triterpenoid glycoside niga-ichigoside F1 (NIF1) and its aglycone 23-hydroxytormentic acid (23-HTA), which were isolated from the unripe fruits of Rubus coreanus (Rosaceae), reduced rheumatoid arthritis (RA) factor and C-reactive protein (CRP) factor in Freund's complete adjuvant reagent-induced rats, suggesting that these two triterpenoids had an anti-rheumatic effect. It was also shown that treatment with NIF1 or 23-HTA reduced gastric lesion extent, acidity and total gastric acid output induced by EtOH plus sodium salicylate in a gastric secretion test. Moreover, 23-HTA had a greater effect than the glycoside, NIF1. To clarify the anti-gastropathic mechanism of these two compounds, their free radical scavenging activities in the gastric mucosa were examined in a rat EtOH-sodium salicylate-induced gastropathy model. The two compounds significantly increased superoxide dismutase and glutathione peroxidase activities, indicating that the healing effects of NIF1 and 23-HTA against gastropathy are associated with free radical scavenging enzyme activities. These results support the notion that the long-term administration of NIF1 or 23-HTA should overcome the adverse effects of synthetic anti-inflammatory drugs.

• Authors: Jung-Hwan Nam, Hyun-Ju Jung, Jongwon Choi, Kyung-Tae Lee, Hee-Juhn Park
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 29 Issue 5 Pg. 967-70 (May 2006) ISSN: 0918-6158 [Print] Japan
• PMID: 16651728 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 23-hydroxytormentic acid
• Anti-Inflammatory Agents, Non-Steroidal
• Anti-Ulcer Agents
• Antirheumatic Agents
• Free Radical Scavengers
• Indicators and Reagents
• Saponins
• Thiobarbituric Acid Reactive Substances
• Triterpenes
• C-Reactive Protein
• Freund's Adjuvant
• niga-ichigoside F1
• Glutathione Peroxidase
• Superoxide Dismutase
• Sodium Salicylate

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal
• Anti-Ulcer Agents
• Antirheumatic Agents
• Arthritis, Experimental (chemically induced, prevention & control)
• C-Reactive Protein (metabolism)
• Free Radical Scavengers (metabolism)
• Freund's Adjuvant
• Fruit (chemistry)
• Gastric Juice (metabolism)
• Gastric Mucosa (drug effects, enzymology, metabolism)
• Glutathione Peroxidase (metabolism)
• Indicators and Reagents
• Male
• Rats
• Rats, Sprague-Dawley
• Rosaceae (chemistry)
• Saponins (chemistry, pharmacology)
• Sodium Salicylate
• Stomach Ulcer (chemically induced, prevention & control)
• Superoxide Dismutase (metabolism)
• Thiobarbituric Acid Reactive Substances (metabolism)
• Triterpenes (chemistry, pharmacology)