Atrial natriuretic peptide in patients with essential hypertension. Hemodynamic, renal, and hormonal responses.

Abstract

In six patients with essential hypertension (EH) and in six healthy volunteers (C) the effects of a 60-min intravenous (iv) infusion of human atrial natriuretic peptide (alpha-hANP) (24 ng/min/kg) on systemic and renal hemodynamics and renal excretory function were evaluated. Basal plasma ANP concentrations in patients with EH were higher (P less than .05) than in C (30.9 +/- 4.5 v14.0 +/- 1.7 pmol/L). Maximal effects of alpha-hANP infusion occurred after 30 to 60 min. Blood pressure (BP) declined from 154 +/- 5/109 +/- 4 to 139 +/- 7/94 +/- 4 in EH and from 117 +/- 1/72 +/- 2 to 106 +/- 1/65 +/- 3 mm Hg in C (P less than .05). Cardiac output (CO) increased transiently from 6.1 +/- 0.3 to 6.5 +/- 0.4 L/min in EH and from 6.8 +/- 0.3 to 7.2 +/- 0.5 L/min in C, whereas heart rate (HR) remained constant both in patients with EH and in C (69 +/- 3 to 72 +/- 5 and 60 +/- 3 to 63 +/- 3/min). The increases in urine flow and in urinary sodium excretion from 3.6 +/- 0.2 to 16.0 +/- 2.0 mL/min and from 230 +/- 33 to 1004 +/- 137 mumol/min, respectively, in EH were more pronounced than in C (from 3.9 +/- 1.0 to 8.4 +/- 0.8 mL/min and from 211 +/- 37 to 451 +/- 84 mumol/min); (P less than .05).(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: H G Predel, O Schulte-Vels, K Glänzer, H Meyer-Lehnert, H J Kramer
• Journal: American journal of hypertension (Am J Hypertens) Vol. 4 Issue 11 Pg. 871-9 (Nov 1991) ISSN: 0895-7061 [Print] United States
• PMID: 1665067 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Vasopressins
• Aldosterone
• Atrial Natriuretic Factor
• Sodium
• Renin
• Cyclic GMP

Topics

• Adult
• Aldosterone (blood)
• Atrial Natriuretic Factor (administration & dosage, blood, pharmacology)
• Blood Pressure (drug effects, physiology)
• Cardiac Output (drug effects, physiology)
• Cyclic GMP (blood)
• Glomerular Filtration Rate (drug effects, physiology)
• Heart Rate (drug effects, physiology)
• Hemodynamics (drug effects, physiology)
• Humans
• Hypertension (blood, physiopathology)
• Infusions, Intravenous
• Kidney (blood supply, metabolism, physiopathology)
• Male
• Regional Blood Flow (drug effects)
• Renin (blood)
• Sodium (urine)
• Vasopressins (blood)