Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate.

Abstract

Phendimetrazine tartrate is a newer drug that acts as a central stimulant and indirectly acting sympathomimetic with a host of uses similar to the class amphetamines. Its main use is as an anorectic in the short-term treatment of obesity, although stimulants are no longer indicated for this purpose. This drug appeals to the younger American population for immediate weight loss through decreased appetite and early satiety. The European Union markets have already withdrawn this medication as well as other countries, but phendimetrazine is still used within the United States. Rhabdomyolysis is a potentially life-threatening complication reported with higher doses of amphetamines. We present a case of rhabdomyolysis and myoglobinuria developing in a 23-year-old patient after oral administration of phendimetrazine tartrate for 3 days in suggested therapeutic doses. The medication was taken for short-term treatment of obesity, and patient did not have any predisposing factors to precipitate rhabdomyolysis. Rhabdomyolysis resolved within 5 days. To our knowledge, this is the first reported case of rhabdomyolysis from administration of therapeutic amounts of phendimetrazine tartrate. The purpose of this case report is to create an awareness among physicians about the potentially life-threatening complications associated with phendimetrazine use as an anorectic even in suggested therapeutic doses as was the case in our patient. Additional awareness is needed to educate their patients about the side effects associated with these drugs and to strongly discourage their unsupervised use.

• Authors: D Kwiker, D Godkar, N Lokhandwala, M Yakoby
• Journal: American journal of therapeutics (Am J Ther) 2006 Mar-Apr Vol. 13 Issue 2 Pg. 175-6 ISSN: 1075-2765 [Print] United States
• PMID: 16645436 (Publication Type: Case Reports, Journal Article)

Chemical References

• Appetite Depressants
• Central Nervous System Stimulants
• Morpholines
• phendimetrazine

Topics

• Adult
• Appetite Depressants (adverse effects, therapeutic use)
• Central Nervous System Stimulants (adverse effects, therapeutic use)
• Humans
• Kidney Function Tests
• Male
• Morpholines (adverse effects, therapeutic use)
• Rhabdomyolysis (chemically induced, physiopathology)
• Water-Electrolyte Imbalance (chemically induced, therapy)