Abstract | PURPOSE: PATIENTS AND METHODS: RESULTS: Partial responses were observed in 6 of the 34 (17.7%) patients enrolled (intention-to-treat analysis; overall response rate: 17.7%; 95% confidence interval 4.8-30.5%). Eight (23.5%) patients experienced disease stabilization and 20 (59%) disease progression ( tumor growth control rate = 41.2%). The median duration of response was 5.5 months, and the median time to tumor progression 2.7 months. The median overall survival was 9.1 months (1-year survival rate: 44.0%). Grade 3 neutropenia and thrombocytopenia occurred in 18 and 15% of the patients, respectively. Other severe non-hematologic toxicities were rare. CONCLUSION: The interesting tumor growth control rate and the favorable toxicity profile of the GEMOX regimen in pretreated patients with advanced CRC strongly suggest that this regimen may provide an alternative therapeutic option for this group of patients.
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Authors | N Ziras, A Potamianou, I Varthalitis, K Syrigos, S Tsousis, I Boukovinas, E Tselepatiotis, C Christofillakis, V Georgoulias |
Journal | Oncology
(Oncology)
Vol. 70
Issue 2
Pg. 106-14
( 2006)
ISSN: 0030-2414 [Print] Switzerland |
PMID | 16645323
(Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2006 S. Karger AG, Basel. |
Chemical References |
- Organoplatinum Compounds
- Deoxycytidine
- Irinotecan
- Leucovorin
- Fluorouracil
- Camptothecin
|
Topics |
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, adverse effects, therapeutic use)
- Camptothecin
(administration & dosage, analogs & derivatives)
- Colorectal Neoplasms
(drug therapy, pathology)
- Deoxycytidine
(administration & dosage, analogs & derivatives)
- Disease Progression
- Disease-Free Survival
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Irinotecan
- Leucovorin
(administration & dosage)
- Male
- Middle Aged
- Organoplatinum Compounds
(administration & dosage)
- Survival Analysis
- Treatment Outcome
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