Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma.

Abstract

Allergic inflammation of the airways has a critical role in asthma development. We investigated a suppressive effect of verproside (3,4-dihydroxy catalpol) isolated from the extract of Pseudolysimachion longifolium on asthmatic parameters--such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, airway hyperresponsiveness and mucus hypersecretion--in an OVA-sensitized/challenged mouse model. Verproside significantly inhibited the increase of total IgE and the cytokines IL-4 and IL-13 in plasma and bronchoalveolar lavage fluid, and also effectively suppressed airway hyperresponsiveness, eosinophilia and mucus hypersecretion in OVA-induced asthmatic mice. The efficacy of verproside was comparable to montelukast, an anti-asthmatic drug that is currently available. These results suggest that verproside could be a major marker in herbal medicines that are used for asthma treatment, and could also act as a lead for anti-asthmatic drugs.

• Authors: Sei-Ryang Oh, Mee Young Lee, Kyungseop Ahn, Bo-Young Park, Ok-Kyuoung Kwon, Hyouk Joung, Joongku Lee, Doo-Young Kim, Sangku Lee, Joo Heon Kim, Hyeong-Kyu Lee
• Journal: International immunopharmacology (Int Immunopharmacol) Vol. 6 Issue 6 Pg. 978-86 (Jun 2006) ISSN: 1567-5769 [Print] Netherlands
• PMID: 16644484 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acetates
• Anti-Asthmatic Agents
• Cyclopropanes
• Glucosides
• Interleukin-13
• Iridoid Glucosides
• Iridoids
• Plant Extracts
• Quinolines
• Sulfides
• verproside
• Methacholine Chloride
• Interleukin-4
• Immunoglobulin E
• Ovalbumin
• montelukast

Topics

• Acetates (pharmacology)
• Animals
• Anti-Asthmatic Agents (isolation & purification, pharmacology, therapeutic use)
• Asthma (chemically induced, drug therapy)
• Bronchoalveolar Lavage Fluid (chemistry, cytology, immunology)
• Cyclopropanes
• Disease Models, Animal
• Female
• Glucosides (isolation & purification, pharmacology, therapeutic use)
• Immunoglobulin E (analysis, blood)
• Interleukin-13 (analysis)
• Interleukin-4 (analysis)
• Iridoid Glucosides
• Iridoids (isolation & purification, pharmacology, therapeutic use)
• Lung (drug effects, metabolism, pathology)
• Methacholine Chloride (pharmacology)
• Mice
• Mice, Inbred BALB C
• Molecular Structure
• Mucus (metabolism)
• Ovalbumin (immunology)
• Plant Extracts (isolation & purification, pharmacology, therapeutic use)
• Pneumonia (chemically induced, drug therapy)
• Pulmonary Eosinophilia (pathology)
• Quinolines (pharmacology)
• Sulfides
• Veronica (chemistry)