Synthesis of cancer-associated glycoantigens: stage-specific embryonic antigen 3 (SSEA-3).

Abstract

The synthesis of the tumor-associated carbohydrate antigens SSEA-3 and Gb3 in a semi-convergent fashion using building blocks bearing a S-thiazolinyl (STaz) moiety is reported. Complete stereoselective control of a difficult alpha-(1-->4)-galactosylation and high overall yields were achieved.

• Authors: Papapida Pornsuriyasak, Alexei V Demchenko
• Journal: Carbohydrate research (Carbohydr Res) Vol. 341 Issue 10 Pg. 1458-66 (Jul 24 2006) ISSN: 0008-6215 [Print] Netherlands
• PMID: 16643871 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antigens, Tumor-Associated, Carbohydrate
• Gb3 antigen
• Glycosphingolipids
• Stage-Specific Embryonic Antigens
• Thiazoles
• stage-specific embryonic antigen-3

Topics

• Antigens, Tumor-Associated, Carbohydrate (chemistry)
• Glycosphingolipids (chemical synthesis)
• Stage-Specific Embryonic Antigens
• Stereoisomerism
• Thiazoles (chemistry)