Outcome analysis for conservative management of Peyronie's disease.

Abstract

BACKGROUND:

We retrospectively analysed the outcomes of conservative management of Peyronie's disease and determined the factors predicting successful outcome.

METHODS:

The study involved 31 patients with Peyronie's disease who were treated at our institute between 1985 and 2003. We assessed the efficacy of vitamin E for the improvement of the symptoms, and the factors which contributed to successful outcome with conservative management using multivariate analysis.

RESULTS:

There was no statistically significant difference in the relief rate between the vitamin E and no-medication groups. The overall estimated relief rate was 67.5% at 2 years from presentation. The multivariate analysis revealed plaque size to be the only significant factor predicting the relief from all symptoms in patients with conservative management. The rate was 100% in patients having a plaque size of 20 mm or smaller and 20.0% in those having a size of larger than 20 mm (P=0.005).

CONCLUSIONS:

We could not confirm the benefit of vitamin E for Peyronie's disease. Plaque size was the only significant factor predicting the relief from all symptoms. Patients with larger plaque might fail to respond to the conservative management.

• Authors: Kohei Hashimoto, Shin-Ichi Hisasue, Ryuichi Kato, Ko Kobayashi, Takashi Shimizu, Taiji Tsukamoto
• Journal: International journal of urology : official journal of the Japanese Urological Association (Int J Urol) Vol. 13 Issue 3 Pg. 244-7 (Mar 2006) ISSN: 0919-8172 [Print] Australia
• PMID: 16643617 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Vitamins
• Vitamin E

Topics

• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Penile Induration (drug therapy, pathology)
• Retrospective Studies
• Severity of Illness Index
• Treatment Outcome
• Vitamin E (therapeutic use)
• Vitamins (therapeutic use)