Abstract | OBJECTIVES: The aim of this controlled clinical trial was to investigate the analgesic efficacy and tolerability of ibuprofen arginine in patients with mild-to-moderate periodontitis during and after non-surgical periodontal treatment. METHODS: RESULTS: The average pain levels during treatment were lower following ibuprofen arginine (quartiles: 0.5, 4.5, 11) compared with placebo (4, 16, 26), corresponding to a percentage reduction in median pain of 72% (p=0.023). The median maximum pain was 28 (inter-quartile range 10-50) following placebo and 10 (4-31) following ibuprofen arginine (p=0.065). CONCLUSIONS: In patients with mild-to-moderate chronic periodontitis, ibuprofen arginine was safe and superior to placebo for alleviating pain during non-surgical periodontal treatment. Its painless administration and rapid onset of action make it well suitable for pain management in a general dental office.
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Authors | Dominik A Ettlin, Andreas Ettlin, Kathrin Bless, Milo Puhan, Corrado Bernasconi, Hans-Christian Tillmann, Sandro Palla, Luigi M Gallo |
Journal | Journal of clinical periodontology
(J Clin Periodontol)
Vol. 33
Issue 5
Pg. 345-50
(May 2006)
ISSN: 0303-6979 [Print] United States |
PMID | 16634956
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Non-Narcotic
- Drug Combinations
- Arginine
- Ibuprofen
- ibuprofen arginine
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Topics |
- Adult
- Aged
- Analgesics, Non-Narcotic
(therapeutic use)
- Arginine
(therapeutic use)
- Chronic Disease
- Dental Scaling
(adverse effects)
- Double-Blind Method
- Drug Combinations
- Female
- Humans
- Ibuprofen
(therapeutic use)
- Male
- Middle Aged
- Pain Measurement
- Periodontitis
(therapy)
- Root Planing
(adverse effects)
- Statistics, Nonparametric
- Toothache
(etiology, prevention & control)
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