Abstract | PURPOSE: METHODS: Thirty-six patients were randomly allocated into one of three groups. Group A received preoperative flurbiprofen axetil, 1 mg x kg(-1). Group B received postoperative flurbiprofen axetil, 1 mg x kg(-1). Group C received a placebo. All groups were given a standardized anesthesia and intravenous morphine via a patient-controlled analgesia device for postoperative analgesia. The pain score was evaluated by a visual analog scale (VAS) at 0 (T(0)), 1 (T(1)), 2 (T(2)), 6 (T(3)), 12 (T(4)), and 24 (T(5)) h after surgery, and the morphine requirement was recorded during the study period. RESULTS: VAS in group A was significantly lower than that in group B at T(0) and T(1). VAS in group A was significantly lower than that in group C throughout the time course after surgery. Postoperative morphine consumption in group A was significantly lower than that in groups B and C at T(0) to T(3). CONCLUSION:
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Authors | Kazunori Yamashita, Makoto Fukusaki, Yuko Ando, Arihiro Fujinaga, Takahiro Tanabe, Yoshiaki Terao, Koji Sumikawa |
Journal | Journal of anesthesia
(J Anesth)
Vol. 20
Issue 2
Pg. 92-5
( 2006)
ISSN: 0913-8668 [Print] Japan |
PMID | 16633764
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Opioid
- Anti-Inflammatory Agents, Non-Steroidal
- Flurbiprofen
- Morphine
- flurbiprofen axetil
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Topics |
- Adult
- Aged
- Analgesics, Opioid
(administration & dosage, therapeutic use)
- Anesthesia, General
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Double-Blind Method
- Female
- Flurbiprofen
(analogs & derivatives, therapeutic use)
- Humans
- Male
- Middle Aged
- Morphine
(administration & dosage, therapeutic use)
- Pain Measurement
- Pain, Postoperative
(prevention & control)
- Preoperative Care
- Spinal Fusion
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