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Preoperative administration of intravenous flurbiprofen axetil reduces postoperative pain for spinal fusion surgery.

AbstractPURPOSE:
The aim of the study was to investigate postoperative analgesia and the opioid-sparing effect of the preoperative administration of intravenous flurbiprofen axetil in patients undergoing spinal fusion surgery.
METHODS:
Thirty-six patients were randomly allocated into one of three groups. Group A received preoperative flurbiprofen axetil, 1 mg x kg(-1). Group B received postoperative flurbiprofen axetil, 1 mg x kg(-1). Group C received a placebo. All groups were given a standardized anesthesia and intravenous morphine via a patient-controlled analgesia device for postoperative analgesia. The pain score was evaluated by a visual analog scale (VAS) at 0 (T(0)), 1 (T(1)), 2 (T(2)), 6 (T(3)), 12 (T(4)), and 24 (T(5)) h after surgery, and the morphine requirement was recorded during the study period.
RESULTS:
VAS in group A was significantly lower than that in group B at T(0) and T(1). VAS in group A was significantly lower than that in group C throughout the time course after surgery. Postoperative morphine consumption in group A was significantly lower than that in groups B and C at T(0) to T(3).
CONCLUSION:
As compared with postoperative administration, preoperative administration of intravenous flurbiprofen axetil provides better postoperative analgesia and an opioid-sparing effect in patients undergoing spinal fusion surgery under general anesthesia.
AuthorsKazunori Yamashita, Makoto Fukusaki, Yuko Ando, Arihiro Fujinaga, Takahiro Tanabe, Yoshiaki Terao, Koji Sumikawa
JournalJournal of anesthesia (J Anesth) Vol. 20 Issue 2 Pg. 92-5 ( 2006) ISSN: 0913-8668 [Print] Japan
PMID16633764 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Analgesics, Opioid
  • Anti-Inflammatory Agents, Non-Steroidal
  • Flurbiprofen
  • Morphine
  • flurbiprofen axetil
Topics
  • Adult
  • Aged
  • Analgesics, Opioid (administration & dosage, therapeutic use)
  • Anesthesia, General
  • Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
  • Double-Blind Method
  • Female
  • Flurbiprofen (analogs & derivatives, therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Morphine (administration & dosage, therapeutic use)
  • Pain Measurement
  • Pain, Postoperative (prevention & control)
  • Preoperative Care
  • Spinal Fusion

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