Abstract | PURPOSE: The reported antibacterial, antiendotoxic, and antiadhesive effects of taurolidine prompted us to study the benefits of intraperitoneal lavage with taurolidine on primary colonic anastomosis in a rat model of secondary peritonitis. METHODS: We induced peritonitis in 40 rats by injecting Escherichia coli isolate intraperitoneally. We performed colonic resection and primary anastomosis 5 h later, after lavage with either taurolidine or saline solution. After the rats were killed, on postoperative day (POD) 3 (n = 10) or 7 (n = 10), we measured the bursting pressures and hydroxyproline levels, then examined the resected specimens histologically. RESULTS: Bursting pressures and tissue hydroxyproline levels were significantly higher in the taurolidine group than in the control group on PODs 3 and 7 (P < 0.05). Histopathological examination revealed significantly higher fibroblastic activity in the taurolidine group. CONCLUSIONS:
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Authors | Aşkin Akkuş, Mustafa Gülmen, Ayhan Cevik, Nejdet Bildik, Orhan Sad, Erdem Oztürk, Nagihan Ozdemir Barişik |
Journal | Surgery today
(Surg Today)
Vol. 36
Issue 5
Pg. 436-40
( 2006)
ISSN: 0941-1291 [Print] Japan |
PMID | 16633750
(Publication Type: Journal Article)
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Chemical References |
- Anti-Infective Agents, Local
- Thiadiazines
- Taurine
- taurolidine
- Hydroxyproline
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Topics |
- Anastomosis, Surgical
- Animals
- Anti-Infective Agents, Local
(pharmacology)
- Colon
(surgery)
- Disease Models, Animal
- Female
- Hydroxyproline
(analysis)
- Peritoneal Lavage
(methods)
- Peritonitis
(drug therapy, etiology)
- Pressure
- Rats
- Rats, Wistar
- Taurine
(analogs & derivatives, pharmacology)
- Thiadiazines
(pharmacology)
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