Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea.

Abstract	A new flavone derivative, chafuroside, has been isolated as a strong anti-inflammatory compound from oolong tea leaves, and its structure determined to be (2R,3S,4S,4aS,11bS)-3,4,11-trihydroxy-2-(hydroxymethyl)-8-(4-hydroxyphenyl)-3,4,4a,11b-tetrahydro-2H,10H-pyrano[2',3':4,5]furo[3,2-g]chromen-10-one. To assess its potential to inhibit intestinal carcinogenesis, 2.5, 5 and 10 p.p.m. chafuroside was given in the diet to Apc-deficient Min mice for 14 weeks from 6 weeks of age. Total numbers of polyps were reduced to 83, 73 and 56% of the control value, respectively. Moreover, dietary administration at 10 and 20 p.p.m. reduced azoxymethane (AOM)-induced colon aberrant crypt foci (ACF) development in rats to 69% of the AOM-treated control value with the higher dose. Chafuroside-associated toxicity was not observed at 2.5-10 p.p.m. in Min mice and 10-20 p.p.m. in AOM-treated rats. These results suggest that chafuroside might be a good chemopreventive agent for colon cancer.
Authors	Naoko Niho, Michihiro Mutoh, Katsuhisa Sakano, Mami Takahashi, Sachiko Hirano, Haruo Nukaya, Takashi Sugimura, Keiji Wakabayashi
Journal	Cancer science (Cancer Sci) Vol. 97 Issue 4 Pg. 248-51 (Apr 2006) ISSN: 1347-9032 [Print] England
PMID	16630115 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Copyright	(Cancer Sci 2006; 97: 248-251).
Chemical References	3,4,11-trihydroxy-2-(hydroxymethyl)-8-(4-hydroxyphenyl)-3,4,4a,11b-tetrahydro-2H,10H-pyrano(2',3'-4,5)furo(3,2-g)chromen-10-one Antineoplastic Agents Flavones Heterocyclic Compounds, 4 or More Rings Tea Azoxymethane
Topics	Animals Antineoplastic Agents (therapeutic use) Azoxymethane (toxicity) Camellia (chemistry) Colonic Neoplasms (chemically induced, prevention & control) Diet Disease Models, Animal Female Flavones (therapeutic use) Heterocyclic Compounds, 4 or More Rings (therapeutic use) Intestinal Mucosa (drug effects) Intestinal Polyps (chemically induced, prevention & control) Male Mice Mice, Inbred C57BL Mice, Knockout Phytotherapy Rats Rats, Inbred F344 Tea

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