Abstract |
Temafloxacin (6-fluoro-7-piperazino-4-quinolone) is a new fluoroquinolone with a 7-8 hour half-life and rapid gastrointestinal absorption. These characteristics make it an ideal antimicrobial for once- or twice-daily oral dosing. With the exception of the central nervous system (CNS), temafloxacin has excellent tissue and body fluid penetration and concentration. Temafloxacin has broad antimicrobial activity against gram-positive and gram-negative bacteria, including improved in vitro activity against Streptococcus pneumoniae, Mycoplasma hominis, and anaerobic bacteria, including Bacteroides fragilis. Temafloxacin is as effective as beta-lactam therapy and superior to ciprofloxacin in the treatment of S. pneumoniae lower respiratory infections. It has been clinically effective when given in a short 3-day regimen for the treatment of uncomplicated urinary tract infections. Multiple clinical trials indicate that temafloxacin is also clinically effective, well tolerated, and safe for use in adult patients for the treatment of other lower respiratory tract, genitourinary tract, and skin and skin-structure infections.
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Authors | G A Pankey |
Journal | The American journal of medicine
(Am J Med)
Vol. 91
Issue 6A
Pg. 166S-172S
(Dec 30 1991)
ISSN: 0002-9343 [Print] United States |
PMID | 1662889
(Publication Type: Journal Article, Review)
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Chemical References |
- Anti-Infective Agents
- Fluoroquinolones
- Quinolones
- temafloxacin
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Topics |
- Anti-Infective Agents
(adverse effects, pharmacology, therapeutic use)
- Bacterial Infections
(drug therapy)
- Fluoroquinolones
- Humans
- Male
- Microbial Sensitivity Tests
- Prostatitis
(drug therapy)
- Quinolones
(adverse effects, pharmacology, therapeutic use)
- Respiratory Tract Infections
(drug therapy)
- Sexually Transmitted Diseases, Bacterial
(drug therapy)
- Skin Diseases, Infectious
(drug therapy)
- Urinary Tract Infections
(drug therapy)
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