Single-dose oral temafloxacin versus parenteral ceftriaxone in the treatment of gonococcal urethritis/cervicitis.

Abstract

Temafloxacin is an oral fluoroquinolone with potent in vitro activity against Neisseria gonorrhoeae. The efficacy and safety of a single dose of temafloxacin were compared with ceftriaxone, the current treatment of choice for gonorrhea, in a randomized, multicenter study. A total of 421 patients with uncomplicated gonococcal urethritis or cervicitis were randomly assigned to receive a single oral dose of temafloxacin 200 mg (n = 63) or 400 mg (n = 175), or a single intramuscular injection of ceftriaxone 250 mg (n = 183). In evaluable patients, bacteriologic cure rates were greater than 99% for both temafloxacin and ceftriaxone recipients. Corresponding clinical cure rates were 93.6% and 94.6%, respectively. Both regimens were well tolerated. A single oral dose of temafloxacin appears to be as safe and effective as injectable ceftriaxone in the treatment of uncomplicated gonococcal urethritis or cervicitis.

• Authors: W J Mogabgab
• Journal: The American journal of medicine (Am J Med) Vol. 91 Issue 6A Pg. 145S-149S (Dec 30 1991) ISSN: 0002-9343 [Print] United States
• PMID: 1662885 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents
• Fluoroquinolones
• Quinolones
• temafloxacin
• Ceftriaxone

Topics

• Administration, Oral
• Adolescent
• Adult
• Aged
• Anti-Infective Agents (administration & dosage, adverse effects)
• Ceftriaxone (administration & dosage, adverse effects)
• Female
• Fluoroquinolones
• Gonorrhea (drug therapy, microbiology)
• Humans
• Injections, Intramuscular
• Male
• Middle Aged
• Quinolones (administration & dosage, adverse effects)
• Urethritis (drug therapy, microbiology)
• Uterine Cervicitis (drug therapy, microbiology)