Abstract | BACKGROUND: METHODS: RESULTS: On histologic examination, fibrotic tissue had decreased in the livers of the AdTbetaTR + AdHGF-treated rats compared with rats that were treated by AdLacZ, AdTbetaTR alone, and AdHGF alone. Liver function, which included serum levels of alanine aminotransferase, improved significantly in AdTbetaTR + AdHGF-treated rats compared with all other groups. The number of hepatocytes that were positive for proliferating-cell nuclear antigen was greater (P < .05) in AdHGF alone and AdTbetaTR + AdHGF-treated rat livers than in AdLacZ- and AdTbetaTR-treated rats. All AdTbetaTR + AdHGF-treated rats survived >60 days, and AdTbetaTR + AdHGF treatment markedly improved the survival rate after a partial hepatectomy. CONCLUSION: Our results suggest that the combination of HGF and TbetaTR gene therapy may increase the possibility of hepatectomy in a cirrhotic liver by improving fibrosis, hepatic function, and hepatocyte regeneration.
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Authors | Satoru Ozawa, Kazuhisa Uchiyama, Mikihito Nakamori, Kentaro Ueda, Makoto Iwahashi, Hikaru Ueno, Yasuteru Muragaki, Akira Ooshima, Hiroki Yamaue |
Journal | Surgery
(Surgery)
Vol. 139
Issue 4
Pg. 563-73
(Apr 2006)
ISSN: 0039-6060 [Print] United States |
PMID | 16627068
(Publication Type: Journal Article)
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Chemical References |
- Receptors, Transforming Growth Factor beta
- Hepatocyte Growth Factor
- Protein Serine-Threonine Kinases
- Receptor, Transforming Growth Factor-beta Type II
- Dimethylnitrosamine
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Topics |
- Adenoviridae
(genetics)
- Animals
- Combined Modality Therapy
- Dimethylnitrosamine
- Disease Models, Animal
- Genetic Therapy
(methods)
- Genetic Vectors
- Hepatectomy
- Hepatocyte Growth Factor
(genetics)
- Humans
- Liver Cirrhosis, Experimental
(surgery, therapy)
- Protein Serine-Threonine Kinases
- Rats
- Receptor, Transforming Growth Factor-beta Type II
- Receptors, Transforming Growth Factor beta
(genetics)
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