Concentrations of azithromycin in human tonsillar tissue.

Abstract

Patients scheduled to undergo tonsillectomy were administered 500 mg oral azithromycin as two 250 mg capsules given 12 h apart. Between 9 h and one week after the second dose, tonsil samples were taken during surgery and assayed for azithromycin. Mean concentrations in tonsillar tissue, 12 and 24 h after the second of the two 250 mg doses given 12 h apart, were 4.5 and 3.9 micrograms/g, respectively. Concurrent mean serum concentrations were approximately 0.03 and 0.01 micrograms/g, respectively. The mean concentration in tonsillar tissue 7.5 days after the last dose was 0.93 micrograms/g. The apparent half-life of drug in the tissue was 76 h. The ratio of mean concentration in tissue to that in serum was greater than 150-fold for all time intervals. The presence of high azithromycin concentrations in tonsillar tissue suggests that a once-daily regimen over five days or less may be effective in treating tonsillo-pharyngitis.

• Authors: G Foulds, K H Chan, J T Johnson, R M Shepard, R B Johnson
• Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (Eur J Clin Microbiol Infect Dis) Vol. 10 Issue 10 Pg. 853-6 (Oct 1991) ISSN: 0934-9723 [Print] Germany
• PMID: 1662631 (Publication Type: Journal Article)

Chemical References

• Capsules
• Erythromycin
• Azithromycin

Topics

• Administration, Oral
• Adult
• Azithromycin
• Capsules
• Chronic Disease
• Drug Administration Schedule
• Erythromycin (administration & dosage, analogs & derivatives, analysis, pharmacokinetics)
• Half-Life
• Humans
• Male
• Palatine Tonsil (chemistry, metabolism)
• Time Factors
• Tonsillitis (metabolism)