| Abstract | BACKGROUND: To evaluate the outcomes of radiation therapy treatment of male patients with breast cancer in our single institutional cohort and discover possible adverse prognostic factors. METHODS: We retrospectively evaluated 42 male patients (median age 55; range 33-77 years) with breast cancer. Patients were irradiated postoperatively in 2 Gy/fraction/day to chest wall +/- lymphatics. RESULTS: Median follow-up was 29 months. Eleven patients had neoadjuvant and 36 patients had adjuvant Adriamycin-based chemotherapy. Nine patients (21%) had local or regional, two (5%) had distant, and one (2.5%) had both local and distant disease at the time of analysis. The actuarial five-year Overall Survival (OS) was 77%, whereas the actuarial five-year Disease-Free (DFS), Locoregional Recurrence-free (LRRFS), and Distant Metastases-Free (DMFS) survival rates were 45%, 69% and 66%, respectively. Univariate analysis of variables, including patient characteristics, treatment modalities and factors, and tumor characteristics, failed to show an association with LRRFS and DFS except percent positive nodal involvement > or = 30% and 50%. CONCLUSION: Though radiotherapy seems quite effective in reducing local recurrence, we have revealed that male breast cancer patients in our cohort with extensive nodal involvement (PPNI >30% and 50%) appeared not to have had a significant benefit from postmastectomy irradiation and adjuvant CMF-based chemotherapy. |
| Authors | Lale Atahan, Ferah Yildiz, Ugur Selek, Sait Sari, Murat Gurkaynak
(Affiliation: Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.)
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| Journal | Journal of the National Medical Association
(J Natl Med Assoc)
Vol. 98
Issue 4
Pg. 559-63
(Apr 2006)
ISSN: 0027-9684 United States |
| PMID | 16623069
(Publication Type: Journal Article)
|
| Topics |
- Actuarial Analysis
- Adult
- Aged
- Breast Neoplasms, Male
(pathology, radiotherapy)
- Carcinoma, Ductal
(pathology, radiotherapy)
- Disease-Free Survival
- Dose Fractionation
- Humans
- Male
- Mastectomy
- Middle Aged
- Neoplasm Recurrence, Local
- Radiotherapy, Adjuvant
- Retrospective Studies
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