Abstract | OBJECTIVES: To determine the frequency, characteristics, treatment and outcome of patients with malignant ovarian germ cell tumor (MOGCT) in King Chulalongkorn Memorial Hospital during the period January 1992 - December 2000. STUDY DESIGN: Retrospective descriptive study MATERIAL AND METHOD: All patients with malignant ovarian germ cell tumor in King Chulalongkorn Memorial Hospital during the period January 1992 - December 2000 were analyzed by the characteristics of patients, treatment and outcome. RESULTS: Sixty-six patients with MOGCT were demonstrated in that period with a mean age of 22.6 years old. Most of the patients were nulliparous and premenopausal status. Primary surgery was done in all patients. Forty-two patients (63.6%) received conservative surgery. Eight patients received no adjuvant treatment after surgery due to stage 1A dysgerminoma and immature teratoma stage I grade I. Fifty-six patients received chemotherapy for adjuvant treatment. VAC regimen was given in 27 cases (40.9%) and PVB regimen was given in 25 cases (37.9%). Salvage therapy in the patients with persistent and recurrent disease was treated in 9 patients, who received a platinum-base of regimen. Two-year survival was 88% with the median time to follow up 24 months. Overall five-year survival in the present study was 85%. CONCLUSION: MOGCT in King Chulalongkorn Memorial Hospital had clinical characteristics similar to other studies in malignant ovarian germ cell tumor Treatment by VAC regimen still has benefit in selected group.
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Authors | Ruangsak Lertkhachonsuk, Wichai Termrungruanglert, Apichai Vasuratna, Tul Sittisomwong, Pongkasem Worasethsin, Damrong Tresukosol |
Journal | Journal of the Medical Association of Thailand = Chotmaihet thangphaet
(J Med Assoc Thai)
Vol. 88 Suppl 4
Pg. S124-8
(Sep 2005)
ISSN: 0125-2208 [Print] Thailand |
PMID | 16623016
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Chemotherapy, Adjuvant
- Child
- Female
- Hospitalization
(statistics & numerical data)
- Hospitals, Urban
(statistics & numerical data)
- Humans
- Incidence
- Middle Aged
- Neoplasms, Germ Cell and Embryonal
(epidemiology, physiopathology, surgery)
- Ovarian Neoplasms
(epidemiology, physiopathology, surgery)
- Radiotherapy, Adjuvant
- Retrospective Studies
- Salvage Therapy
- Survival Analysis
- Thailand
(epidemiology)
- Treatment Outcome
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