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Expression of p53, Ki-67 and c-erb B2 in growth hormone-and/or prolactin-secreting pituitary adenomas.

Abstract
The subcellular events implicated on the formation and behavior of pituitary adenomas are not fully understood. In this study we investigated the presence of p53, Ki-67 and c-erb B2 in 38 pituitary adenomas with immunohistochemical positivity for GH and prolactin (n=26; 68.4%), for prolactin (n=9; 23.7%) and for GH (n=3. 7.8%). The analyses revealed the following results: 24 (63.2%) tumors expressed variable positivity for c-erb B2, 11 (28.9%) expressed p53 positivity and 11 (28.9%) tumors were variably positive for Ki-67. Our results demonstrated a high percentage of GH/prolactin-, prolactin- and GH-secreting tumors with immunohistochemical positivity for c-erb B2. Once this membrane receptor is related to growth factors EGF and TGFalpha and both have a definite effect on tumor growth, our data suggest a possible role for c-erb B2 on the evolution of these tumors.
AuthorsCarlos Henrique A Botelho, Albino Verçosa de Magalhães, Paulo Andrade de Mello, Fernando C Schmitt, Luiz Augusto Casulari
JournalArquivos de neuro-psiquiatria (Arq Neuropsiquiatr) Vol. 64 Issue 1 Pg. 60-6 (Mar 2006) ISSN: 0004-282X [Print] Germany
PMID16622555 (Publication Type: Journal Article)
Chemical References
  • Ki-67 Antigen
  • Neoplasm Proteins
  • Tumor Suppressor Protein p53
  • Growth Hormone
  • Receptor, ErbB-2
Topics
  • Adolescent
  • Adult
  • Female
  • Growth Hormone (metabolism)
  • Humans
  • Immunohistochemistry
  • Ki-67 Antigen (analysis)
  • Male
  • Middle Aged
  • Neoplasm Proteins (analysis)
  • Pituitary Neoplasms (metabolism, pathology)
  • Prolactinoma (metabolism, pathology)
  • Receptor, ErbB-2 (analysis)
  • Tumor Suppressor Protein p53 (analysis)

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