Abstract |
The subcellular events implicated on the formation and behavior of pituitary adenomas are not fully understood. In this study we investigated the presence of p53, Ki-67 and c-erb B2 in 38 pituitary adenomas with immunohistochemical positivity for GH and prolactin (n=26; 68.4%), for prolactin (n=9; 23.7%) and for GH (n=3. 7.8%). The analyses revealed the following results: 24 (63.2%) tumors expressed variable positivity for c-erb B2, 11 (28.9%) expressed p53 positivity and 11 (28.9%) tumors were variably positive for Ki-67. Our results demonstrated a high percentage of GH/ prolactin-, prolactin- and GH-secreting tumors with immunohistochemical positivity for c-erb B2. Once this membrane receptor is related to growth factors EGF and TGFalpha and both have a definite effect on tumor growth, our data suggest a possible role for c-erb B2 on the evolution of these tumors.
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Authors | Carlos Henrique A Botelho, Albino Verçosa de Magalhães, Paulo Andrade de Mello, Fernando C Schmitt, Luiz Augusto Casulari |
Journal | Arquivos de neuro-psiquiatria
(Arq Neuropsiquiatr)
Vol. 64
Issue 1
Pg. 60-6
(Mar 2006)
ISSN: 0004-282X [Print] Germany |
PMID | 16622555
(Publication Type: Journal Article)
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Chemical References |
- Ki-67 Antigen
- Neoplasm Proteins
- Tumor Suppressor Protein p53
- Growth Hormone
- Receptor, ErbB-2
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Topics |
- Adolescent
- Adult
- Female
- Growth Hormone
(metabolism)
- Humans
- Immunohistochemistry
- Ki-67 Antigen
(analysis)
- Male
- Middle Aged
- Neoplasm Proteins
(analysis)
- Pituitary Neoplasms
(metabolism, pathology)
- Prolactinoma
(metabolism, pathology)
- Receptor, ErbB-2
(analysis)
- Tumor Suppressor Protein p53
(analysis)
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