Abstract |
Up-regulation of polyamine transporters on the surface of tumor cells and the internalization of biogenic polyamines by active transport processes may be exploited for the accumulation of spermidine derivatives as reporter molecules. We have synthesized and tested fluorophor-labeled spermidine derivatives for the development of a new class of intraoperative tumor imaging agents. In vitro uptake experiments and initial in vivo imaging studies illustrated that fluorophor tagged spermidine derivatives show tumor accumulation.
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Authors | Markus Wolf, Ulrike Bauder-Wüst, Rüdiger Pipkorn, Helmut Eskerski, Michael Eisenhut |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 16
Issue 12
Pg. 3193-6
(Jun 15 2006)
ISSN: 0960-894X [Print] England |
PMID | 16621552
(Publication Type: Journal Article)
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Chemical References |
- Fluorescent Dyes
- Spermidine
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Topics |
- Animals
- Cell Line, Tumor
- Fluorescent Dyes
(chemistry)
- Mice
- Mice, Nude
- Microscopy, Confocal
- Molecular Structure
- Neoplasm Transplantation
- Neoplasms
(pathology)
- Spermidine
(analogs & derivatives, chemistry, pharmacology)
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