Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.

Abstract

Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the Ki values of 21 and 25 microM, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated.

• Authors: Tan Siew Kiat, Richard Pippen, Rohana Yusof, Halijah Ibrahim, Norzulaani Khalid, Noorsaadah Abd Rahman
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 16 Issue 12 Pg. 3337-40 (Jun 15 2006) ISSN: 0960-894X [Print] England
• PMID: 16621533 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cyclohexanes
• Flavonoids
• Protease Inhibitors
• cyclohexenyl chalcone
• Chalcone
• NS3 protease, dengue virus
• Serine Endopeptidases

Topics

• Chalcone (analogs & derivatives, chemistry, pharmacology)
• Cyclohexanes (chemistry, pharmacology)
• Flavonoids (chemistry, pharmacology)
• Molecular Structure
• Plant Roots (chemistry)
• Protease Inhibitors (chemistry, pharmacology)
• Serine Endopeptidases (metabolism)
• Zingiberaceae (chemistry)