Abstract | BACKGROUND: MATERIALS AND METHODS: The mRNA expression of PTPN3 and PTPN4 by RT-PCR was investigated, and the protein expression status of PTPN3 was examined, using immunohistochemistry, to elucidate clinicopathological associations of the PTPN3 and PTPN4 family within human stomach cancer. RESULTS: PTPN3 and PTPN4 were expressed in all gastric cancer cell lines and clinical cancer tissue specimens examined. Following the examination of 92 gastric cancer patients' pathological specimens, PTPN3 expression showed no statistical significance with respect to the patients' survival. A statistically significant correlation between PTPN3 staining and the differentiation status of gastric cancer tissue was, however, observed. CONCLUSION: This finding indicates that both PTPN3 and PTPN4 are expressed within human gastric cancer cells and that PTPN3 seems to play an important role in gastric cancer differentiation and the progression of malignancy.
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Authors | Chew-Wun Wu, Jen-Hao Chen, Hwa-Li Kao, Anna F Y Li, Chun-Hun Lai, Chin-Wen Chi, Wen-Chang Lin |
Journal | Anticancer research
(Anticancer Res)
2006 Mar-Apr
Vol. 26
Issue 2B
Pg. 1643-9
ISSN: 0250-7005 [Print] Greece |
PMID | 16619586
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- RNA, Messenger
- PTPN3 protein, human
- Protein Tyrosine Phosphatase, Non-Receptor Type 3
- Protein Tyrosine Phosphatases
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Topics |
- Adenocarcinoma
(enzymology, genetics)
- Aged
- Cell Line, Tumor
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Protein Tyrosine Phosphatase, Non-Receptor Type 3
- Protein Tyrosine Phosphatases
(biosynthesis, genetics)
- RNA, Messenger
(biosynthesis, genetics)
- Reverse Transcriptase Polymerase Chain Reaction
- Stomach Neoplasms
(enzymology, genetics)
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