Abstract | BACKGROUND:
TZT-1027 ( Soblidotin), an antimicrotubule drug, has shown potent antitumor efficacy in various antitumor models, and has entered into phase I clinical trials. To determine those anticancer drugs to be combined with TZT-1027 in clinical trials, the combination effects of TZT-1027 with other anticancer drugs were examined. MATERIALS AND METHODS: RESULTS: A significant increase in lifespan was observed when TZT-1027 was combined with CDDP, GEM and CPT-11 in the P388 cell ascites tumor model, and a significant inhibition of growth was observed when TZT-1027 was combined with CDDP, GEM and DTX in the A549 solid tumor model. Sequential administration, particularly when the combined drug was administered first, showed the most potent antitumor efficacy. CONCLUSION: These findings strongly suggest that a significant combination effect of TZT-1027 and these antitumor drugs can be expected in clinical trials for solid tumors.
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Authors | Tsugitaka Natsume, Jun-Ichi Watanabe, Toshi Horiuchi, Motohiro Kobayashi |
Journal | Anticancer research
(Anticancer Res)
2006 Mar-Apr
Vol. 26
Issue 2A
Pg. 1145-51
ISSN: 0250-7005 [Print] Greece |
PMID | 16619516
(Publication Type: Journal Article)
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Chemical References |
- Oligopeptides
- Taxoids
- Deoxycytidine
- Docetaxel
- Irinotecan
- soblidotin
- Paclitaxel
- Cisplatin
- Fluorouracil
- Camptothecin
- Gemcitabine
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Topics |
- Animals
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage)
- Camptothecin
(administration & dosage, analogs & derivatives)
- Carcinoma, Non-Small-Cell Lung
(drug therapy)
- Cisplatin
(administration & dosage)
- Deoxycytidine
(administration & dosage, analogs & derivatives)
- Docetaxel
- Drug Administration Schedule
- Drug Screening Assays, Antitumor
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Irinotecan
- Leukemia P388
(drug therapy)
- Lung Neoplasms
(drug therapy)
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Oligopeptides
(administration & dosage)
- Paclitaxel
(administration & dosage)
- Taxoids
(administration & dosage)
- Gemcitabine
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