Effect of lemnan, pectin from Lemna minor L., and its fragments on inflammatory reaction.
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| Abstract |
An effect of apiogalacturonanic pectin of duckweed Lemna minor L. (lemnan LM) was studied on the inflammatory response to ovalbumin injected intradermally into the footpad of control and ovalbumin-fed mice. Lemnan LM (1-2 mg per mouse) was found to enhance by as much as 50-60% the footpad swelling in control mice. Oral administration of ovalbumin was shown to result in sensitization that increased inflammation. Ovalbumin admixed with lemnan was found to increase by two-fold footpad edema in comparison with the mice receiving ovalbumin alone. Apple pectin used as a reference compound failed to influence the inflammatory reaction. Degradation of lemnan was performed to elucidate the active region of the polysaccharide macromolecule. The apiogalacturonanic fragment (LMP) obtained using a digestion of lemnan LM with pectinase was shown to increase the footpad response in both control and ovalbumin-fed mice. Fragment LMPH deprived of some terminal apiose residues as a result of partial acidic hydrolysis failed to have an effect on the inflammatory response.Thus, the data obtained reveal an enhancement by lemnan of the inflammatory response. The ramified apiogalacturonan seemed to be the active region of the lemnan macromolecule.
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| Authors | Sergey V Popov, Raisa G Ovodova, Yury S Ovodov |
| Journal | Phytotherapy research : PTR (Phytother Res) Vol. 20 Issue 5 Pg. 403-7 (May 2006) ISSN: 0951-418X [Print] England |
| PMID | 16619370 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright 2006 John Wiley & Sons, Ltd. |
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