HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Marked efficacy of a therapeutic strategy associating prednisone and plasma exchange followed by rituximab in two patients with refractory myopathy associated with antibodies to the signal recognition particle (SRP).

Abstract
We report two patients with myopathy associated with anti-signal recognition particle Ab, refractory to conventional therapy, who were treated with prednisone and plasma exchange, followed by rituximab. A marked response was observed in both patients, with partial to complete recovery of muscle strength, which was sustained.
AuthorsJean-Benoit Arlet, Dalia Dimitri, Christian Pagnoux, Olivier Boyer, Thierry Maisonobe, François-Jérome Authier, Coralie Bloch-Queyrat, Claire Goulvestre, Farhad Heshmati, Marielle Atassi, Loïc Guillevin, Serge Herson, Olivier Benveniste, Luc Mouthon
JournalNeuromuscular disorders : NMD (Neuromuscul Disord) Vol. 16 Issue 5 Pg. 334-6 (May 2006) ISSN: 0960-8966 [Print] England
PMID16616848 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • Autoantibodies
  • Immunologic Factors
  • Signal Recognition Particle
  • Rituximab
  • Prednisone
Topics
  • Adult
  • Anti-Inflammatory Agents (administration & dosage)
  • Antibodies, Monoclonal (administration & dosage)
  • Antibodies, Monoclonal, Murine-Derived
  • Antibody Formation (drug effects, immunology)
  • Autoantibodies (immunology)
  • B-Lymphocytes (drug effects, immunology)
  • Clinical Protocols (standards)
  • Disease Progression
  • Female
  • Humans
  • Immunologic Factors (administration & dosage)
  • Male
  • Muscle, Skeletal (immunology, pathology, physiopathology)
  • Muscular Diseases (diagnosis, physiopathology, therapy)
  • Plasma Exchange (methods)
  • Prednisone (administration & dosage)
  • Rituximab
  • Signal Recognition Particle (immunology)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: