Aleatory clinical study comparing otilonium bromide with a fiber-rich diet in the treatment of irritable bowel syndrome.

Abstract

We studied 114 patients affected by irritable bowel syndrome (IBS) (group A = 53 patients, group B = 61). Group A received diet with high content of roughage (20 g of fibers) and 10 g of bran, group B received otilonium bromide (OB) 40mg tid and normal diet (10-15 g of fibers). Abdominal pain, abdominal distension, bowel movements were evaluated before treatment (T0) at the end (T24) and after 12 months (T12). In group B otilonium bromide induced a significant improvement (p less than 0.01) of abdominal pain and distension when comparing T0 with T24. In group A diet produced an improvement, albeit not significant, of the aforementioned parameters at T24. On the basis of our data OB seems to be more effective than a high-fiber diet in the treatment of IBS.

• Authors: M Villagrasa, J Boix, P Humbert, J C Quer
• Journal: The Italian journal of gastroenterology (Ital J Gastroenterol) Vol. 23 Issue 8 Suppl 1 Pg. 67-70 (Nov 1991) ISSN: 0392-0623 [Print] Italy
• PMID: 1661630 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Dietary Fiber
• Parasympatholytics
• Quaternary Ammonium Compounds
• octylonium

Topics

• Abdominal Pain (therapy)
• Adult
• Colonic Diseases, Functional (therapy)
• Dietary Fiber (therapeutic use)
• Evaluation Studies as Topic
• Female
• Follow-Up Studies
• Humans
• Male
• Parasympatholytics (therapeutic use)
• Quaternary Ammonium Compounds (therapeutic use)
• Time Factors