[Clinical study on preventive effect of fuzheng quxie granule on respiratory viral infection].

Abstract

OBJECTIVE:

To evaluate the effect of Fuzheng Quxie granule (FQG) on immune cells and cytokines of populations susceptible to respiratory viral infection.

METHODS:

One thousand four hundred and two subjects selected from 25 hospitals in Shanghai between May and June in 2003, were divided into the FQG group treated with FQG and the control group treated with placebo. Serum levels of interleukin 2 (IL-2), interleukin 4 (IL-4), gamma-interferon (gamma-IFN), blood lymphocyte subsets (CD3+ , CD4+, CD8+), B-cell count and natural killer cell (NK) percent ratio were measured in 130 of the FQG group and 120 of the control group before treatment, by the end of the 2nd week and two weeks after treatment.

RESULTS:

By the end of the 2nd week of treatment, as compared with before treatment, the levels of IL-2, gamma-IFN, and NK percent in the FQG group increased significantly (P < 0.05), while IL-4 and CD3+, CD4+, CD8+ and B-cell count were unchanged. Besides, levels of Th1/Th2 ratio markedly increased at the end of the 2nd week and two weeks after treatment, in comparing with that before treatment and in the control group (P<0.05).

CONCLUSION:

FQG could improve immune function of population susceptible to respiratory viral infection certain extent.

• Authors: Jing-Cheng Dong, Zhao-Hua Gong, Yu-Hua Liu, Jinyu Xie, Xiaohui Dong, Fudong Zhao, Yan Cui
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 26 Issue 3 Pg. 215-7 (Mar 2006) ISSN: 1003-5370 [Print] China
• PMID: 16613264 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• Interleukin-2
• Interleukin-4
• Interferon-gamma

Topics

• Adult
• CD4-CD8 Ratio
• Double-Blind Method
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Humans
• Interferon-gamma
• Interleukin-2 (blood)
• Interleukin-4 (blood)
• Killer Cells, Natural (immunology)
• Male
• Middle Aged
• Phytotherapy
• Respiratory Tract Infections (prevention & control)
• Virus Diseases (prevention & control)