[Pancreatic acinar cell carcinoma successfully treated with combination of oral TS-1 and intra-arterial cisplatin].

Abstract

Pancreatic acinar cell carcinomas are rare, and little is reported on their chemotherapy. We report a 49-year old male patient with pancreatic acinar cell carcinoma and multiple liver metastases, which responded to oral TS-1 and hepatic arterial infusion of cisplatin. The patient underwent a partial hepatectomy, MCT abrasions and excision of the pancreatic tumor. Postoperative pathological studies revealed metastases of acinar cell carcinoma to the liver and lymph nodes; the primary lesion was undetermined. After surgery, the patient was treated with hepatic arterial infusion of cisplatin and oral TS-1. Metastatic tumors completely disappeared, and serum lipase decreased to normal levels. Abdominal CT one year after surgery revealed a pancreatic body tumor, which was surgically removed. Pathological studies showed primary pancreatic acinar cell carcinoma, while previous metastases remained under control. To summarize, TS-1 and cisplatin can be effective treatments for pancreatic acinar cell carcinomas.

• Authors: Yoshiki Kataoka, Yoshinori Nio, Seiji Yano, Makoto Koike, Koji Hashimoto, Masayuki Itakura, Tomoko Itagaki, Takeshi Nishi, Shinichiro Endo, Tetsuya Higami
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 33 Issue 4 Pg. 525-8 (Apr 2006) ISSN: 0385-0684 [Print] Japan
• PMID: 16612167 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Pyridines
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Cisplatin

Topics

• Administration, Oral
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Acinar Cell (drug therapy, secondary, surgery)
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Drug Administration Schedule
• Drug Combinations
• Hepatectomy
• Humans
• Infusions, Intra-Arterial
• Liver Neoplasms (drug therapy, secondary, surgery)
• Male
• Middle Aged
• Oxonic Acid (administration & dosage)
• Pancreatic Neoplasms (drug therapy, pathology, surgery)
• Pyridines (administration & dosage)
• Tegafur (administration & dosage)