Abstract | AIM: METHODS: RESULTS: CCl(4) induction led to the damage of liver and development of fibrosis in Group B and Group C rats when compared to Group A rats. The treatment of WeiJia in Group C rats could reduce the fibrosis condition significantly compared to Group B rats. The effect could be observed after three weeks of treatment and was more obvious after eight weeks of treatment. Serum HA, CIV, ALT, AST and gamma-GT levels after eight weeks of treatment for Group C rats were 58+/-22 microg/L (P<0.01), 57+/-21 microg/L (P<0.01), 47+/-10 U/L (P<0.01), 139+/-13 U/L (P<0.05) and 52+/-21 U/L (P>0.05) respectively, similar to normal control group (Group A), but significantly different from CCl(4) induced liver injury control group (Group B). An increase in PCNA and decrease in alpha-SMA expression level was also observed. CONCLUSION:
WeiJia could improve liver function and reduce liver fibrosis which might be through the inhibition of stellate cell activity.
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Authors | Pik-Yuen Cheung, Qi Zhang, Ya-Ou Zhang, Gan-Rong Bai, Marie Chia-Mi Lin, Bernard Chan, Chi-Chun Fong, Lin Shi, Yue-Feng Shi, Jay Chun, Hsiang-Fu Kung, Mengsu Yang |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 12
Issue 12
Pg. 1912-7
(Mar 28 2006)
ISSN: 1007-9327 [Print] United States |
PMID | 16609998
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Actins
- Collagen Type IV
- Peptides
- Proliferating Cell Nuclear Antigen
- Proteins
- WeiJia
- smooth muscle actin, rat
- Hyaluronic Acid
- Carbon Tetrachloride
- gamma-Glutamyltransferase
- Aspartate Aminotransferases
- Alanine Transaminase
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Topics |
- Actins
(analysis)
- Alanine Transaminase
(blood)
- Animals
- Aspartate Aminotransferases
(blood)
- Carbon Tetrachloride
- Collagen Type IV
(blood)
- Female
- Hyaluronic Acid
(blood)
- Liver
(drug effects)
- Liver Cirrhosis
(blood, chemically induced, drug therapy, pathology)
- Male
- Peptides
(pharmacology, therapeutic use)
- Proliferating Cell Nuclear Antigen
(analysis)
- Proteins
(pharmacology, therapeutic use)
- Rats
- Rats, Wistar
- gamma-Glutamyltransferase
(blood)
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