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Clinicopathological and immunohistochemical analysis of malignant features in mucinous cystic tumors of the pancreas.

AbstractBACKGROUND/AIMS:
To investigate the malignancy of mucinous cystic tumors (MCTs) of the pancreas, we examined clinicopathological features and immunohistochemical findings of MCT.
METHODOLOGY:
We analyzed the expression of p53 protein, proliferating cell nuclear antigen, alpha6-integrin subunit, alpha5beta1-integrin, and interleukin-1 receptor type I in tumor specimens from eight patients with MCT.
RESULTS:
The tumors were classified as mucinous cyst adenoma (n=6) or mucinous cyst adenocarcinoma (n=2). The actuarial five-year survival rate was 83.3%. All in eight MCTs had 'ovarian-type' stroma in the cyst wall. The alpha6-integrin subunit and p53 protein were expressed in adenocarcinoma tissues of MCTs, and in two adenomas the alpha6-integrin subunit and p53 protein were also co-expressed.
CONCLUSIONS:
Our present results indicate that coexpression of the alpha6-integrin subunit and p53 protein should be appreciated as an indicator of malignancy in MCTs.
AuthorsHirozumi Sawai, Yiuji Okada, Hitoshi Funahashi, Yoichi Matsuo, Tetsushi Hayakawa, Moritsugu Tanaka, Hiromitsu Takeyama, Tadao Manabe
JournalHepato-gastroenterology (Hepatogastroenterology) 2006 Mar-Apr Vol. 53 Issue 68 Pg. 286-90 ISSN: 0172-6390 [Print] Greece
PMID16608041 (Publication Type: Journal Article)
Chemical References
  • Integrin alpha5beta1
  • Integrin alpha6
  • Proliferating Cell Nuclear Antigen
  • Receptors, Interleukin-1
  • Receptors, Interleukin-1 Type I
  • Tumor Suppressor Protein p53
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Cystadenocarcinoma, Mucinous (metabolism, pathology)
  • Cystadenoma, Mucinous (metabolism, pathology)
  • Female
  • Humans
  • Integrin alpha5beta1 (metabolism)
  • Integrin alpha6 (metabolism)
  • Male
  • Middle Aged
  • Pancreatic Neoplasms (metabolism, pathology)
  • Proliferating Cell Nuclear Antigen (metabolism)
  • Receptors, Interleukin-1 (metabolism)
  • Receptors, Interleukin-1 Type I
  • Tumor Suppressor Protein p53 (metabolism)

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