Abstract | BACKGROUND/AIMS: To investigate the malignancy of mucinous cystic tumors (MCTs) of the pancreas, we examined clinicopathological features and immunohistochemical findings of MCT. METHODOLOGY: RESULTS: The tumors were classified as mucinous cyst adenoma (n=6) or mucinous cyst adenocarcinoma (n=2). The actuarial five-year survival rate was 83.3%. All in eight MCTs had 'ovarian-type' stroma in the cyst wall. The alpha6-integrin subunit and p53 protein were expressed in adenocarcinoma tissues of MCTs, and in two adenomas the alpha6-integrin subunit and p53 protein were also co-expressed. CONCLUSIONS: Our present results indicate that coexpression of the alpha6-integrin subunit and p53 protein should be appreciated as an indicator of malignancy in MCTs.
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Authors | Hirozumi Sawai, Yiuji Okada, Hitoshi Funahashi, Yoichi Matsuo, Tetsushi Hayakawa, Moritsugu Tanaka, Hiromitsu Takeyama, Tadao Manabe |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
2006 Mar-Apr
Vol. 53
Issue 68
Pg. 286-90
ISSN: 0172-6390 [Print] Greece |
PMID | 16608041
(Publication Type: Journal Article)
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Chemical References |
- Integrin alpha5beta1
- Integrin alpha6
- Proliferating Cell Nuclear Antigen
- Receptors, Interleukin-1
- Receptors, Interleukin-1 Type I
- Tumor Suppressor Protein p53
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Cystadenocarcinoma, Mucinous
(metabolism, pathology)
- Cystadenoma, Mucinous
(metabolism, pathology)
- Female
- Humans
- Integrin alpha5beta1
(metabolism)
- Integrin alpha6
(metabolism)
- Male
- Middle Aged
- Pancreatic Neoplasms
(metabolism, pathology)
- Proliferating Cell Nuclear Antigen
(metabolism)
- Receptors, Interleukin-1
(metabolism)
- Receptors, Interleukin-1 Type I
- Tumor Suppressor Protein p53
(metabolism)
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