Oral regimen consisting of UFT/UZEL for elderly patients with colorectal cancer.

Abstract

BACKGROUND/AIMS:

A clinical trial has been planned to assess the safety and efficacy of oral administration of UFT and leucovorin (UZEL) in elderly patients with advanced colorectal cancer (CRC).

METHODOLOGY:

Twenty-six patients with advanced CRC who were over 70 years and considered ineligible for combination chemotherapy received oral UFT 300 mg/day and UZEL 75mg/day were administered orally for 28 days followed by a 7-day rest period. Treatment was repeated every 5 weeks until disease progression.

RESULTS:

A total of 106 cycles of UFT/UZEL were administered (median, four cycles; range, one to twelve cycles). UFT/UZEL was well tolerated. The response rate was 11% (3 partial responses, 16 stable diseases, and 7 progressive diseases). The median progression-free survival rate was 3.9 months and the median survival time was 9.8 months. Treatment-related grade 3 and 4 adverse events were not observed.

CONCLUSIONS:

Oral regimen consisting of UFT/ UZEL is effective and well tolerated in elderly patients with advanced CRC who are considered ineligible for combination chemotherapy.

• Authors: Soichi Tsutsumi, Satoru Yamaguchi, Kaori Tsuboi, Takaharu Fukasawa, Sayaka Yamaki, Takayuki Asao, Hiroyuki Kuwano
• Journal: Hepato-gastroenterology (Hepatogastroenterology) 2006 Mar-Apr Vol. 53 Issue 68 Pg. 209-12 ISSN: 0172-6390 [Print] Greece
• PMID: 16608026 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Vitamin B Complex
• Tegafur
• Uracil
• Leucovorin

Topics

• Administration, Oral
• Aged
• Aged, 80 and over
• Antineoplastic Agents (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
• Colorectal Neoplasms (drug therapy, mortality, pathology)
• Drug Administration Schedule
• Female
• Humans
• Leucovorin (administration & dosage)
• Male
• Survival Rate
• Tegafur (administration & dosage)
• Treatment Outcome
• Uracil (administration & dosage)
• Vitamin B Complex (administration & dosage)