Abstract | PURPOSE: DESIGN: Prospective, randomized, double-masked clinical trial. PARTICIPANTS: METHODS: Patients scheduled for routine phacoemulsification and intraocular lens implantation were provided either moxifloxacin 0.5% ophthalmic solution (n = 22) or gatifloxacin 0.3% ophthalmic solution (n = 24) to use 4 times daily the day before surgery plus 1 drop 1 hour before the surgical entry into the anterior chamber on the day of surgery. This regimen simulated a realistic postoperative dosing schedule. Aqueous humor samples were obtained and analyzed by high-pressure liquid chromatography. Aqueous humor fluoroquinolone concentrations were calculated by peak comparison with a known concentration peak for ciprofloxacin that was used as an internal standard. These values were compared with published concentrations of other available fluoroquinolones under similar dosing conditions. RESULTS: The mean age of the moxifloxacin 0.5% group was 67.8+/-9.7 years, whereas that of the gatifloxacin 0.3% group was 69.9+/-8.7 years. The moxifloxacin AH concentration was 1.86+/-1.06 microg/ml, and that of gatifloxacin was 0.94+/-0.72 microg/ml. This 2-fold difference was statistically significant (P = 0.001). CONCLUSIONS:
|
Authors | J P McCulley, D Caudle, J D Aronowicz, W E Shine |
Journal | Ophthalmology
(Ophthalmology)
Vol. 113
Issue 6
Pg. 955-9
(Jun 2006)
ISSN: 1549-4713 [Electronic] United States |
PMID | 16603244
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anti-Bacterial Agents
- Aza Compounds
- Fluoroquinolones
- Ophthalmic Solutions
- Quinolines
- Gatifloxacin
- Moxifloxacin
|
Topics |
- Administration, Topical
- Aged
- Anti-Bacterial Agents
(pharmacokinetics)
- Aqueous Humor
(metabolism)
- Aza Compounds
(pharmacokinetics)
- Biological Availability
- Chromatography, High Pressure Liquid
- Double-Blind Method
- Female
- Fluoroquinolones
(pharmacokinetics)
- Gatifloxacin
- Humans
- Lens Implantation, Intraocular
- Male
- Microbial Sensitivity Tests
- Moxifloxacin
- Ophthalmic Solutions
(pharmacokinetics)
- Phacoemulsification
- Prospective Studies
- Quinolines
(pharmacokinetics)
|